Prediction of tablet properties based on near infrared spectra of raw mixed powders by chemometrics: Scale-up factor of blending and tableting processes.

The purpose of this research was to develop a method of prediction based on near-infrared (NIR) spectra of raw mixed powders before compression by using chemometrical means. The effect of the difference in scale up using a pilot-scale mixing machine and a continuous tableting machine was studied. The formulation consisted of sulpyrine, microcrystalline cellulose, and 1% magnesium stearate.

Prediction of tablet hardness based on near infrared spectra of raw mixed powders by chemometrics.

The purpose of this research is to elucidate the effect of lubricant mixing on tablet hardness by near-infrared (NIR) chemometrics as a basic study of process analytical technology. Formulation cellulose (F-C) consisted of sulpyrine (SP), microcrystalline cellulose (MC), and magnesium stearate (MgSt). Formulation lactose/starch (F-L) consisted of SP bulk drug powder, spray-dried lactose (SL), corn starch (CS), and MgSt.

Inhibition of a solid phase reaction among excipients that accelerates drug release from a solid dispersion with aging.

Hydrophobic drug substances can be formulated as a solid dispersion or solution using macromolecular matrices with high glass transition temperatures to attain satisfactory dissolution. However, very few marketed products have previously relied on solid dispersion technology due to physical and chemical instability problems, and processing difficulties. In the present study, a modified release product of a therapeutic drug for hypertension, Barnidipine hydrochloride, was developed.