Effects of changing from sevoflurane to desflurane on the recovery profile after sevoflurane induction: a randomized controlled study.

Purpose: Desflurane has the lowest solubility of currently available volatile anesthetics and may allow for more rapid emergence and recovery compared with sevoflurane. Nevertheless, after volatile induction with sevoflurane, it has not been determined whether the use of desflurane provides faster emergence and recovery. The present study aimed to elucidate the effects of changing from sevoflurane to desflurane during the early part of anesthesia.

Enhanced effects of isoflurane on the long QT syndrome 1-associated A341V mutant.

Background: The impact of volatile anesthetics on patients with inherited long QT syndrome (LQTS) is not well understood. This is further complicated by the different genotypes underlying LQTS. No studies have reported on the direct effects of volatile anesthetics on specific LQTS-associated mutations.

Partial restoration of the long QT syndrome associated KCNQ1 A341V mutant by the KCNE1 β-subunit.

Background: The A341V mutation in the pore-forming KCNQ1 subunit of the slowly activating delayed-rectifier potassium current (IKs) underlies a common form of the long QT syndrome, and is associated with an unusually severe phenotype. However, there is controversy regarding the underlying mechanism responsible for the clinically observed phenotype. We investigated the biophysical characteristics of A341V in a cardiac environment by utilizing a cardiac cell line, and in particular the impact of the KCNE1 β-subunit.

Efficacy of intrathecal morphine with epidural ropivacaine infusion for postcesarean analgesia.

Study Objective: To evaluate the analgesia following cesarean delivery and the frequency of side effects of intrathecal morphine when combined with a continuous epidural infusion.

Design: Randomized, double-blinded study.

Setting: University hospital.