Publications by authors named "Ikumi Abe"
Diallyl disulfide reduced dose-dependently the number of lymphocyte subsets and monocytes in rats.
J Nutr Sci Vitaminol (Tokyo)
April 2013
Article Synopsis
- Diallyl disulfide (DADS), a key sulfur compound in garlic, has anti-inflammatory and immune-modulating effects, but its impact on white blood cell distribution is not fully understood.
- A study on male Sprague Dawley rats explored how varying doses of DADS (10, 20, 40 mg/kg) affected white blood cell counts and plasma corticosterone levels.
- Results showed that DADS decreased total white blood cells and lymphocyte subsets, especially T- and B-lymphocytes, while increasing corticosterone levels, indicating a dose-dependent reduction in specific immune cells.
Objective: Folate (vitamin B(9)) plays key roles in cell growth and proliferation through regulating the synthesis and stabilization of DNA and RNA, and its deficiency leads to lymphocytopenia and granulocytopenia. However, precisely how folate deficiency affects the distribution of a variety of white blood cell subsets, including the minor population of basophils, and the cell specificity of the effects remain unclear. Therefore, we examined the effects of a folate-deficient diet on the circulating number of lymphocyte subsets [T-lymphocytes, B-lymphocytes, and natural killer (NK) cells] and granulocyte subsets (neutrophils, eosinophils, and basophils) in rats.
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