Publications by authors named "Ikuei Hirota"
Histochemical analysis of the biphasic properties of formalin pain-induced behavior.
Biochem Biophys Rep
July 2023
The formalin test has been established as a method for evaluating mouse models of pain. Although there have been numerous reports of formalin-pain-induced behavior, few reports of a detailed histochemical analysis of the central nervous system focus on behavioral biphasic properties. To investigate the alternation of spinal neuronal activity with formalin-induced pain, we performed immunofluorescent staining with c-Fos antibodies as neuronal activity markers using acute pain model mice induced by 2% formalin stimulation.
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- Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by ulcers in the colon, and its exact cause remains unclear, highlighting the need for new treatments.
- The study explored a silicon-based agent that generates hydrogen in the gastrointestinal tract, showing potential to relieve both mental and gastrointestinal symptoms linked to UC through its antioxidant properties.
- The agent demonstrated effectiveness in a mouse model, suggesting it could help reduce flare-ups and maintain remission in UC patients.