Publications by authors named "Ikuan Sam"
CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble form. CXCR6 is a marker for resident memory T (T) cells that plays a role in immunosurveillance through their interaction with epithelial cells. The interaction of CXCR6 with CXCL16 expressed at the membrane of certain subpopulations of intratumor dendritic cells (DC) called DC3, ideally positions these CXCR6 T cells to receive a proliferation signal from IL-15 also presented by DC3.
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- CD70 is a costimulatory molecule that activates CD27-expressing T cells, with clear-cell renal cell carcinoma (ccRCC) showing high levels of CD70 but unclear clinical implications.
- The study analyzed tissue from 25 ccRCC patients for CD27 and CD70 expression and assessed T-cell traits using flow cytometry and single-cell RNA sequencing, alongside measuring soluble CD27 (sCD27) in 81 RCC patients undergoing immunotherapy.
- Results indicated that CD27+ T cells were dysfunctional in ccRCC and high levels of sCD27 predicted poor survival in RCC patients treated with specific immunotherapies, suggesting that sCD27 could serve as a predictive biomarker for immunotherapy resistance in various tumors.
Gastric cancer is one of the deadliest cancers worldwide. An accurate prognosis is essential for effective clinical assessment and treatment. Spatial patterns in the tumor microenvironment (TME) are conceptually indicative of the staging and progression of gastric cancer patients.
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