Publications by authors named "Ikram-Allah Tanouti"
Impact of and variants on HIV-1 susceptibility and progression to AIDS: a case-control study in a Moroccan population.
Nucleosides Nucleotides Nucleic Acids
November 2024
Interleukin-6 (IL-6), a pro-inflammatory cytokine, is an important regulator of the inflammatory immune response. We aimed to assess the association of common single nucleotide polymorphisms (SNPs) in (rs1800795 G > C, rs1800797 A > G) and () (rs2228145 A > C) genes with HIV-1 infection, AIDS progression, and response to treatment. In this case-control study involving 199 individuals living with HIV-1 and 200 HIV-uninfected controls, we conducted genotyping of SNPs using TaqMan real-time PCR assays.
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- SARS-CoV-2 symptoms range from none to severe, with some cases involving serious complications and death, and genetic factors may impact infection risk and severity.
- The study focuses on specific IL-6 gene variants (rs1800795 and rs1800797) in a Moroccan population to assess their link to virus susceptibility and COVID-19 severity.
- While no significant links were found between the gene variants and susceptibility, specific haplotypes (GC* and AG*) were associated with a reduced risk of SARS-CoV-2 infection.
Article Synopsis
- Chronic inflammation caused by hepatitis B (HBV) and C (HCV) increases interleukin 6 (IL-6) levels, which can lead to liver damage and increase the risk of developing hepatocellular carcinoma (HCC).
- A study with 314 participants, including 157 HCC patients, found significantly higher IL-6 levels in HCC patients compared to controls, especially in those with metabolic liver disease.
- Despite higher IL-6 levels in HCC patients, genetic variants rs1800795 and rs1800797 of the IL-6 gene did not show a significant association with the risk of developing HCC.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a primary liver cancer, and the study focuses on the role of the PPARGC1A gene in HCC risk among Moroccans.* -
- Researchers found that individuals with certain genetic variations (GA/AA) of the PPARGC1A gene had a significantly higher risk of developing HCC compared to those with the GG variant.* -
- While one genetic variant (rs8192678) showed a strong association with HCC risk, another variant (rs12640088) did not, highlighting the potential for using rs8192678 as a marker for liver cancer prognosis.*
Article Synopsis
- Chronic hepatitis B virus (CHB) infection is a significant public health issue, and the study focuses on whether the PPARGC1A gene variant (Gly482Ser) affects the spontaneous clearance of HBV and chronic disease progression in Moroccan patients.
- The research involved 292 CHB patients and 181 individuals who cleared the virus, analyzing a specific SNP (rs8192678) to assess its relationship with HBV outcomes.
- Findings indicate that certain genotypes (CT and TT) in the rs8192678 variant are linked to higher spontaneous clearance rates, while no significant connection was found between this variant and the progression of liver disease in CHB patients.
Association between and genetic variants and the risk of hepatocellular carcinoma in Moroccan population.
Nucleosides Nucleotides Nucleic Acids
November 2023
Hepatocellular carcinoma (HCC) is the fifth most common human malignancy and the fourth most frequent cause of cancer-related deaths worldwide. Toll-like receptors (TLRs), are known to play a key role in hepatocarcinogenesis through induction of inflammation. We aimed to investigate the association between rs3804099, rs4986790, rs4986791, and rs11536889 and 5 rs5744174 and HCC risk in a total of 306 Moroccan subjects, including 152 HCC patient and 154 controls using a TaqMan allelic discrimination assay.
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- Eight viruses are classified as carcinogenic or probably carcinogenic to humans, including HPV, hepatitis B and C, EBV, HTLV-1, HHV-8, Merkel cell polyomavirus, and HIV-1.
- These viruses are linked to over 14,000 cancer cases annually in Morocco, but not everyone infected will develop cancer.
- Host genetic factors and lifestyle choices could influence the risk of cancer, suggesting that understanding these interactions may help in early detection and prevention strategies.