Influence of first line chemotherapy strategy depending on primary tumor location in metastatic colorectal cancer.

Background: Primary tumor location (PTL) is a major prognostic factor in metastatic colorectal cancer (mCRC) with left side which present better prognosis than right sided. Uncertainty exists regarding comparative effectiveness of irinotecan or oxaliplatin doublet in mCRC in function of PTL.

Methods: We conducted a retrospective comparing clinical outcomes from both regimens in function of sidedness.

Influence of primary tumor location and resection on survival in metastatic colorectal cancer.

Background: Patients with right sided colorectal cancer are known to have a poorer prognosis than patients with left sided colorectal cancer, whatever the cancer stage. To this day, primary tumor resection (PTR) is still controversial in a metastatic, non resectable setting.

Aim: To explore the survival impact of PTR in patients with metastatic colorectal cancer (mCRC) depending on PTL.