Beyond Amyloid: A Machine Learning-Driven Approach Reveals Properties of Potent GSK-3β Inhibitors Targeting Neurofibrillary Tangles.

Current treatments for Alzheimer's disease (AD) focus on slowing memory and cognitive decline, but none offer curative outcomes. This study aims to explore and curate the common properties of active, drug-like molecules that modulate glycogen synthase kinase 3β (GSK-3β), a well-documented kinase with increased activity in tau hyperphosphorylation and neurofibrillary tangles-hallmarks of AD pathology. Leveraging quantitative structure-activity relationship (QSAR) data from the PubChem and ChEMBL databases, we employed seven machine learning models: logistic regression (LogR), k-nearest neighbors (KNN), random forest (RF), support vector machine (SVM), extreme gradient boosting (XGB), neural networks (NNs), and ensemble majority voting.

Chronic HIV infection and health related quality of life in resource poor settings-an assessment from South East Nigeria.

Background: Health-related quality of life reflects a patient's general subjective perception of the effect of an illness or intervention on physical, psychological and social aspects of daily life. HIV infection is a major public health problem especially in developing countries where poor health infrastructure and poverty are prevalent. This paper addresses the quality of life in patients with chronic HIV infection in South East Nigeria and addresses issues that may help improve the current situation.

Conceptual framework for establishing the African Stroke Organization.

Africa is the world's most genetically diverse, second largest, and second most populous continent, with over one billion people distributed across 54 countries. With a 23% lifetime risk of stroke, Africa has some of the highest rates of stroke worldwide and many occur in the prime of life with huge economic losses and grave implications for the individual, family, and the society in terms of mental capital, productivity, and socioeconomic progress. Tackling the escalating burden of stroke in Africa requires prioritized, multipronged, and inter-sectoral strategies tailored to the unique African epidemiological, cultural, socioeconomic, and lifestyle landscape.

Headache prevalence and its characterization amongst hospital workers in Enugu, South East Nigeria.

Background: Headaches are probably the commonest neurological complaint worldwide. Amongst workers it contributes significantly to loss of productive time and work efficiency. It is an important cause of disability and reduced quality of life.

Knowledge, attitude and practice of epilepsy among community residents in Enugu, South East Nigeria.

Purpose: The understanding of the opinions of the Nigerian public about epilepsy and its treatment is relevant to the reduction of the large treatment gap that exists in management of the condition. The major aim of this study was to determine the knowledge and attitudes of urban dwellers to epilepsy and its treatment and to identify the gaps in knowledge that could pose as barriers in the treatment and care of epilepsy patients within the community.

Method: This cross-sectional and descriptive study was carried out in one of the districts of Enugu metropolis, Nigeria.

Frequency and pattern of headache among medical students at Enugu, South East Nigeria.

Objective: To ascertain frequency and pattern of primary headaches among young Nigerians as represented by medical students in the University of Nigeria, Enugu Campus, South East Nigeria.

Methods: This was a cross-sectional descriptive interview-based study using structured headache questionnaire. Consent was obtained and the results interpreted following the guidelines of the International Headache Society.

Ischaemic stroke in hyperthyroidism without cardiac arrhythmia. A case report from south east Nigeria.

Background: The relationship between hyperthyroidism and stroke is well established in the setting of atrial fibrillation. However there is limited literature for ischaemic stroke occuring in hyperthyroidism without cardiac arrhythmia. No such case had been described in South East Nigeria.

Critical care of myasthenia gravis in a resource poor setting: a study of South East Nigeria.

Background: Myasthenia gravis presenting as a neurologic emergency warrants management in a critical care unit. In resource poor settings which typify much of Africa, this can be very challenging even in tertiary centers with consequently unfavorable outcomes.

Aim: This study evaluated the outcomes of intensive care management of patients with myasthenia gravis in a regional teaching hospital in South East Nigeria.