Some biochemical and haematological changes in rats pretreated with aqueous stem bark extract of Lophira lanceolata and intoxicated with paracetamol (acetaminophen).

Background: This study investigated the acute toxicity effect of aqueous stem bark extract of Lophira lanceolata and the activities of liver enzymes and other markers of organ damage in rats pretreated with aqueous stem bark extract of L. lanceolata extract and subsequently intoxicated with paracetamol (PCM).

Methods: A total of 30 rats were used to determine the acute toxicity of aqueous extract of L.