The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris.

Background: Epidermal growth factor receptor inhibitors (EGFRI) used in cancer chemotherapy cause acneiform folliculitis in 70%-100% of patients in a dose-dependent manner. Acneiform folliculitis is considered to be caused by an inflammatory process due to follicular hyperkeratosis and subsequently a set of changes both in epidermis and hair follicles as a result of epidermal growth factor receptor (EGFR) blockade. Both acne vulgaris and acneiform folliculitis due to EGFRIs show similar changes in the pilosebaceous unit.

Association of Leukotrichia in Vitiligo and Asp148Glu Polymorphism of Apurinic/Apyrimidinic Endonuclease 1.

Background: Oxidative stress and increased DNA damage have been implicated in the etiopathogenesis of vitiligo. Oxidative DNA damage is mainly repaired by the base excision repair (BER) pathway.

Aim: We sought to determine whether polymorphisms in DNA repair genes may have a role in the pathogenesis of vitiligo.

The Evaluation of Endothelin-1 and Endothelin Receptor Type A Gene Polymorphisms in Patients with Vitiligo.

Background: Endothelin-1 (EDN1) and EDN receptor type A (EDNRA) are implicated in melanocyte functions.

Aim And Objectives: This study examines the role of EDN1 (G5665T and T-1370G) and EDNRA (C + 70G and G-231A) polymorphisms as a risk factor for vitiligo, and evaluates the relationship between genotypes and clinical characteristics of vitiligo patients.

Materials And Methods: We analyzed genotype/allele distributions of EDN1 and EDNRA polymorphisms in 100 patients with vitiligo and 185 healthy controls by real-time polymerase chain reaction.

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus.

Background: Previous studies have shown that some viral infections may be triggers for autoimmune diseases. The role of viral infections in the etiopathogenesis of pemphigus has also been investigated.

Objectives: To investigate the relationship between pemphigus and the hepatitis B and C virus infections.

Arborizing vessels under dermoscopy: a case of cellular neurothekeoma instead of basal cell carcinoma.

Neurothekeoma is a slow-growing, benign tumor of nerve sheath origin. Herein we present a 62-year-old female who presented with a 5-month history of a nodule that had shown a slight enlargement. She had a diagnosis of non-Hodgkin lymphoma for 10 years for which she had received multiple sessions of chemotherapy and radiotherapy.

Characteristics of fever, etiologic factors, antibiotic use and prognosis in febrile dermatology inpatients.

Background: Generally, fever is observed in >30% of hospitalized patients. However, little is known about fever in dermatology inpatients.

Objectives: The aim of this study was to investigate and document the incidence, characteristics, and etiologic factors of fever in febrile dermatology inpatients and to describe the practice of antibiotic use and prognosis in the same group.

Sclerosing cellular blue nevus simulating melanoma.

Sclerosing blue nevus is an uncommon variant of common blue nevus and shows an amorphous blue appearance at the edges with a hypopigmented center. Herein we present a 48-year-old female with sclerosing cellular blue nevus with extraordinary clinical and dermoscopic features simulating melanoma. The association of a whitish scarlike area with a pigmented dot pattern prominent throughout the lesion was unusual for a sclerosing cellular blue nevus.

Analysis of vitamin D receptor gene polymorphisms in vitiligo.

Background: Vitiligo is a progressive depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. The etiopathogenesis of vitiligo is still unclear. Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells.

Clinicopathological consistency in skin disorders: a retrospective study of 3949 pathological reports.

Background: Although the clinicopathological approach plays an important role in skin disorder diagnoses, few studies have evaluated the consistency between clinical and histopathological diagnoses of skin disorders.

Objective: We sought to investigate the consistency, and factors affecting consistency, between clinical diagnoses and pathological diagnoses in patients with skin disorders referred for biopsy by dermatologists.

Methods: We retrospectively examined 3949 pathological reports of biopsy specimens, between 1999 and 2008.

Canine scabies in humans: a case report and review of the literature.

Background: Sarcoptes scabiei causes mange in many domestic and wild mammals, and it has been reported to be transmitted from animals to humans. Canine scabies is known to infest humans, as well.

Case Report: We report a 27-year-old woman who presented with severe pruritic papules on the trunk and arms.

Iododerma following sitz bath with povidone-iodine.

A 50-year-old man developed numerous pustules and bullae on the trunk and limbs 15 days after anal fissure surgery. The clinicopathological diagnosis was iododerma induced by topical povidone-iodine sitz baths postoperatively. Complete resolution occurred within 3 weeks using systemic corticosteroids and forced diuresis.

Colocalization of lipedematous scalp and nevus lipomatosus superficialis: a case report.

Lipedematous scalp (LS) is a rare condition of unknown etiology characterized by a thick, boggy scalp that occurs mostly in adult black females. The main pathologic finding consists of increased thickness of scalp resulting from thickening of the subcutaneous fat layer. Nevus lipomatosus superficialis (NLS) is an uncommon hamartomatous skin tumor characterized by soft, yellowish papules, or cerebriform plaques, usually localized on the buttock or thigh.

HHV-8 positive Kaposi sarcoma in a patient with end-stage renal disease undergoing hemodialysis: no regressive effect of captopril.

Human herpesvirus 8 (HHV-8) has been associated with Kaposi sarcoma (KS) in renal transplant recipients. On the other hand, there are only a few reported cases of KS in patients with end stage renal failure receiving hemodialysis. Here, we report a case of HHV-8 positive, disseminated KS, in a 70-year-old man with renal failure, receiving hemodialysis for 7 months.

Case of keratosis lichenoides chronica with atypical sarcoidal granulomatous inflammation.

Keratosis lichenoides chronica (KLC) is a rare chronic disease characterized by violaceous, papular and nodular lesions typically arranged in a linear and reticulate pattern. The etiology of KLC is unknown, but it may be associated with internal diseases such as hypothyroidism, glomerulonephritis and lymphoproliferative disorders. Herein, we describe the case of 44-year-old male patient with characteristic lesions of KLC on the trunk and extremities, present for 12 years.