Background: Epalrestat (EPL) is a carboxylic acid derivative with poor aqueous solubility and its pharmacokinetic features are not fully defined.
Purpose: Current research aimed to fabricate inclusion complexation of EPL with SBE β-CD (IC) and EPL/SBE β-CD CS NPs (NP).
Methods: EPL was complexed with SBE β-CD using the co-precipitation method, and the prepared complex was fabricated into nanoparticles using the ionic gelation method.
The nomadic pastoral indigenous communities of the Ladakhi people share roots with Tibetan culture in terms of food, clothing, religion, festivals, and habits, and rely widely on plant resources for survival and livelihood. This survey was conducted during 2019-2021 to document the indigenous knowledge about plant resources of the Balti, Beda, and Brokpa communities of the Ladakh region, trans-Himalayas. Open- and close-ended semi-structured interviews (N = 184) and group discussions (N = 17) were used to collect the data.
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