Monoclonal antibodies to human chorionic gonadotropin and their application to two-site sandwich radioimmunoassay.

Monoclonal antibodies were prepared against human chorionic gonadotropin (HCG). One monoclonal antibody recognized a conformational determinant expressed only on native HCG molecule and another monoclonal antibody had the specificity for the epitopes located on the beta-subunit of HCG. Monoclonal antibodies reacting with different antigenic determinants on the HCG molecule were used to develop a simplified 2-site sandwich radioimmunoassay in which one monoclonal antibody was immobilized and another labeled with 125iodine.

Intraarterial digital subtraction angiography of peripheral arteries with isotonic contrast material.

Intraarterial digital subtraction angiography (IADSA) of peripheral arteries with isotonic contrast material, which was prepared by diluting meglumine amidotrizoate (65% Angiografin), was performed in ten patients. In six, both IADSA and conventional screen-film arteriography were performed for comparison. Painless peripheral arteriography was achieved by IADSA with isotonic contrast material.

Intraarterial digital subtraction arteriography in the management of renal tumors.

Nine patients with renal tumors were studied by intraarterial digital subtraction arteriography (IADSA). Embolization was performed in six patients. IADSA was evaluated on the following practical points: vascular mapping, renal vein visualization, and embolization.

Multilocular cystic hepatocellular carcinoma.

We report an unusual case of multilocular cystic hepatocellular carcinoma. The patient was a 42-year-old woman without liver cirrhosis but who had three multicystic mass lesions in the liver. Transcatheter arterial embolization was very effective and a survival time of more than 19 months was obtained.

[Positron emission tomographic studies using C-11-glucose in normal aging and cerebrovascular dementia].

Seven normal volunteers and 11 patients with cerebrovascular dementia were studied about the relations between effect of aging, severity of dementia, cerebral glucose metabolism and metabolic response to verbal stimuli by positron emission tomography (PET) using C-11-glucose administered orally. The diagnosis of cerebrovascular dementia was done according to the Hachinski's ischemic score and X-ray CT findings, and the severity of dementia was classified according to the DR scale originated by Hasegawa. PET scanning started at 10 minutes and ended at 50 minutes after administration of C-11-glucose, and bloods were sampled at every 5-10 minutes during the PET scanning .

Internal jugular phlebectasia in children.

Two pediatric cases with internal jugular phlebectasia which showed specific clinical and radiographic features are described. CT and venography were useful in the diagnosis. Differential diagnosis of cervical masses which enlarge with Valsalva maneuver are also discussed with a review of the literature.

Bilateral synchronous renal cancer.

Six cases of concurrent bilateral renal cancer are reported. These cases represented 3.7% of 163 renal cancers in our institute during the period 1965-1983.

Sclerosing hepatic carcinoma: a report of a case treated with a transcatheter arterial embolization.

Sclerosing hepatic carcinoma (SHC) is one of the variant primary liver carcinomas and is characterized by intense fibrosis which surrounds slender cords of neoplastic cells. We report on a 53-year-old male patient with SHC describing the radiological findings and clinical course after a transcatheter arterial embolization. To our knowledge, this was only the second reported case of SHC in Japan.

Intraarterial digital subtraction portography in patients with liver tumors.

Intraarterial digital subtraction portography (IADSP) via the superior mesenteric artery was performed in 50 patients with liver tumors. In most cases IADSPs provided images as good as conventional arterial portography through the superior mesenteric artery and they produced important information as to whether patients should be treated by transcatheter arterial embolization, surgical resection or chemotherapy. IADSP helps to reduce the examination time, the number of films and contrast material used, as well as the pain suffered by patients.

Magnetic resonance of liver tumors: a preliminary report.

Early experience in magnetic resonance (MR) images of the liver tumors is reported, based on 25 cases examined by a 0.35T superconducting machine (Magnetom, Siemens) using the spin echo technique. All main liver tumors were demonstrated as high intensity areas of varying degree in the spin echo image with a TR of 1,600 msec and a TE of 70 msec.

Hepatocellular carcinoma treated by transcatheter arterial embolization: progress evaluated by computed tomography.

Computed tomography (CT) was performed after 65 transcatheter arterial embolizations (TAE) in 50 patients with hepatocellular carcinoma. Nonenhanced high-density areas were seen in the tumors within 3 days in 17/25 cases (though they soon disappeared) and low-density areas within 2 weeks in 62/65. Gas bubbles were seen in these areas within 2 weeks in 60% of embolizations.

Magnetic resonance imaging of brain tumors: measurement of T1. Work in progress.

Longitudinal relaxation times (T1) of 20 brain tumors were calculated in vivo using a whole-body magnetic resonance unit with a 0.15-T resistive magnet. Images employing standard inversion recovery pulse sequences with different intervals between the 180 degrees pulse and selective excitation pulses were compared on every point of the 256 X 256 pixel matrix.

Bone scintigraphy in Maffucci syndrome.

Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia associated with multiple enchondromas and hemangiomas. The high risk of development of malignant tumors is well-known. A case of Maffucci syndrome in a 68-year-old man who suffered from multiple malignant degeneration and who was given a bone scintigraphic examination is reported with radiological and pathological findings.

Mesenteric varices: an entity with specific clinical, angiographic features.

Eight Japanese patients with mesenteric varices were diagnosed by angiography. All patients suffered from portal hypertension and had a history of previous abdominal surgery or peritonitis. The mesenteric varices of these patients were thought to be related to adhesion.

[Visualization of cerebellopontine angle diseases by nuclear magnetic resonance imaging].

The preliminary results from the clinical use a prototype whole body nuclear magnetic resonance (NMR) machine constructed by Toshiba Inc. are presented. Cranial NMR scans were performed on more than 30 cases with broad spectrum of neurologic diseases using saturation-recovery and inversion-recovery sequences with a field strength of 1500 Gauss.

[Computed tomography of suprasellar cystic lesions].

Difficulties are often encountered in the differential diagnosis of suprasellar cystic lesions in computed tomography (CT). During the past 5 years and 7 months we experienced 22 such cases. In this report we tried to review the characteristic CT findings for the differential diagnosis of these lesions.

Functional imaging of thallium-201 myocardial washout and the clinical utility of this method.

In exercise testing with Thallium-201 myocardial scintiscan, we developed a quantitative myocardial Tl-201 washout image, a washout ratio and a washout index to detect ischemic segments. The washout value was measured with a pixel by pixel calculation between counts of the initial image and images that were delayed for three hours after the initial image. We compared the color displayed functional washout images with the original image in the detection of ischemic segments which had been confirmed by coronary angiography.

ECG-gated NMR-CT for cardiovascular disease.

We have developed an ECG-gated NMR-CT, and used it with 16 patients. The saturation recovery images are not able to separate heart muscle from the blood pool, but in inversion recovery images, heart muscle can be differentiated from the ventricles. The region of myocardial infarction is revealed as wall thinning and/or wall motion abnormality.

Gelatin gel beads as an embolic agent.

Gelatin gel beads (GGB) is a compound of a long-chain polypeptide cross-linked with glutaraldehyde. It has been produced exclusively for embolic purposes. The object of the tests reported here was to determine the efficacy of GGB as an embolic agent in dogs as initial studies with rats had shown no acute toxic reaction.