A macroscopic anatomical study of the appropriate palpation zone of the gluteus medius muscle.

[Purpose] Few previous studies have delimitated the palpation zone of the gluteus medius muscle with a focus on its fiber bundles. The purpose of this study was to clarify the morphological characteristics of the gluteus medius muscle using an anatomical approach, and to define its proper palpation zone. [Participants and Methods] In this study, we evaluated thirteen halves of the pelvic region in seven formalin-fixed cadavers.

Brain Diseases and Fall-Related Surgery in Older Persons.

Background: It is known that age-related brain symptoms (gait difficulty and dementia) increase the likelihood of fall-related surgery. In contrast, it is not known which types of brain disease underlie such symptoms most.

Objective: The aim of this study was to correlate brain diseases with the types of surgeries performed at our hospital for patients who had fallen.

Probable Creutzfeldt-Jakob Disease Presenting Dementia and Urinary Retention.

We describe the case of an 80-year-old woman with probable Creutzfeldt-Jakob disease (CJD) presenting dementia and urinary retention. Although the number of patients previously examined, including ours, is small for conclusion, provided that other etiologies of urinary retention are carefully excluded, urinary retention seems to become a feature in CJD, presumably reflecting spinal cord pathology in CJD. Physicians are advised to evaluate pelvic floor function in CJD particularly by checking post-void residuals.

Role of TrkA signaling during tadpole tail regeneration and early embryonic development in Xenopus laevis.

Neurotrophic signaling regulates neural cell behaviors in development and physiology, although its role in regeneration has not been fully investigated. Here, we examined the role of neurotrophic signaling in Xenopus laevis tadpole tail regeneration. After the tadpole tails were amputated, the expression of neurotrophin ligand family genes, especially ngf and bdnf, was up-regulated as regeneration proceeded.

Young-Onset Dementia with Lewy Bodies.

Young-onset (< 65 years) dementia is a challenging clinical problem. A 61-year-old man visited our clinic because of a 2-year history of mild cognitive impairment of the executive disorder type. He was initially suspected of having young-onset Alzheimer's disease due to the lack of motor signs or hippocampal atrophy by conventional brain MRI.

Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.

Herein we describe the discovery and characterization of a novel, piperidine-based inhibitor of cholesteryl ester transfer protein (CETP) with a core structure distinct from other reported CETP inhibitors. A versatile synthesis starting from 4-methoxypyridine enabled an efficient exploration of the SAR, giving a lead molecule with potent CETP inhibition in human plasma. The subsequent optimization focused on improvement of pharmacokinetics and mitigation of off-target liabilities, such as CYP inhibition, whose improvement correlated with increased lipophilic efficiency.

Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin.

The transient receptor potential vanilloid type 1 (TRPV1) is a thermosensitive cation channel that triggers heat pain in the periphery. Long-term desensitization of TRPV1, which can be induced by excess amounts of agonists, has been a method for investigating the physiological relevance of TRPV1-containing neuronal circuits, and desensitization induced by various routes of administration, including systemic, intrathecal and intraganglionic, has been demonstrated in rodents. In the present study, we examined the effect of intracerebroventricular (i.

Efficacy of a leukotriene receptor antagonist for pediatric cedar pollen allergy complicated by asthma.

Leukotriene receptor antagonists (LTRAs) are identified as a monotherapy for asthma and allergic rhinitis; however, their use in children for treatment of these diseases has not been examined. Accordingly, the present study investigated the efficacy of pranlukast dry syrup for children with both pollinosis and asthma. The subjects were children receiving treatment for asthma who were also diagnosed with cedar pollen allergy.

The retroesophageal right subclavian artery - A case report and review.

In a student course of gross anatomy dissection at Kanagawa Dental University in 2011, we encountered anomalous case of the right subclavian artery arising from the aortic arch as the last branch in an 84-year-old Japanese male cadaver. The anomalous artery ran obliquely upward, passed behind the esophagus and trachea, and ultimately ran toward right scalene gap. The area of distribution of the anomalous artery was normal.

A Study of the Maxillary Sinus Volume in Elderly Persons Using Japanese Cadavers.

In this paper, using full-body CT images of elderly and advanced elderly Japanese cadavers, we measure maxillary and other paranasal sinus volumes in order to examine the effects of age, sex, presence or absence of maxillary molars, and other factors on changes to maxillary sinus volume. The research subjects consisted of 77 of 95 cadavers donated to the Kanagawa Dental University between 2012 and 2014, which average age was 82.6 ± 10 years (33 were male, average age 79.

The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis.

Background: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the small GTPase Rac1. However, the role of HACE1 in early development remains unknown.

Microcirculation alterations in experimentally induced gingivitis in dogs.

The present study aimed to morphologically examine the gingival microvascular network using a microvascular resin cast (MRC) technique, and to investigate how inflammatory disease functionally affects gingival microcirculation using laser Doppler flowmetry (LDF). We used four beagle dogs with healthy periodontal tissue as experimental animals. To cause periodontal inflammation, dental floss was placed around the cervical neck portions of the right premolars.

Anatomical study of the coexistence of the postaortic left brachiocephalic vein with the postaortic left renal vein with a review of the literature.

In a student course of gross anatomy dissection at Kanagawa Dental University in 2009, we found an extremely rare case of the coexistence of the postaortic left brachiocephalic vein with the postaortic left renal vein of a 73-year-old Japanese male cadaver. The left brachiocephalic vein passes behind the ascending aorta and connects with the right brachiocephalic vein, and the left renal vein passes behind the abdominal aorta. These two anomalous cases mentioned above have been reported respectively.

Morphological observation of the horseshoe kidney with circumaortic venous ring.

In a student course of gross anatomy dissection at Knagawa Dental College in 2010, we found an extremely rare case of the horseshoe kidney with circumaortic venous ring in a 43-year-old Japanese male cadaver. In this case, the kidney consisted of three parts: the original kidneys on both sides and an isthmus between them. The location of each kidney was lower than that of the normal kidney.

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling.

The Hippo signalling pathway has emerged as a key regulator of organ size, tissue homeostasis, and patterning. Recent studies have shown that two effectors in this pathway, YAP/TAZ, modulate Wnt/β-catenin signalling through their interaction with β-catenin or Dishevelled, depending on biological contexts. Here, we identify a novel mechanism through which Hippo signalling inhibits Wnt/β-catenin signalling.

Double superior vena cava and anomaly of cardiovascular system with a review of the literature.

In a student course of gross anatomy dissection at Kanagawa Dental College in 2008, we found an extremely rare case of the double superior vena cava that has a shunt between the right and left atria of a 81-year-old Japanese male cadaver. The left superior vena cava passed through the space between the left cardiac auricle and the left pulmonary vein and entered the coronary sulcus. Then it opened near the opening of the inferior vena cava as the coronary venous sinus to the right atrium.

An odontometric study of the maxillary molars in Australian marsupials. I. The koala (Phascolarctos cinereus).

Crown dimensions of the maxillary molars were measured in the koala (Phascolarctos cinereus). There were no significant differences in crown diameters between the first and second molars, however the fourth molars were reduced in all crown diameters. The third molar was smaller than the first or second molars in buccolingual crown diameters but there were no significant differences in mesiodistal crown diameters.

Anomalous bifurcation and island formation of the carotid artery.

An anomalous artery directly connecting the common carotid artery and internal carotid artery was discovered on the right side in the cadaver of an 83-year-old Japanese female, and the facial artery, maxillary artery, and superficial temporal artery arose from the common carotid artery by a common trunk. The anomalous artery arose from the posterior aspect of the common carotid artery at the level of the origin of the superior thyroid artery, and joined the posterior aspect of the internal carotid artery. The anomalous artery was covered by the connective tissue surrounding the common carotid artery and the internal carotid artery.

Anti-influenza virus principles from Muehlenbeckia hastulata.

Extracts of Chilean medicinal plants were evaluated in vitro for their activities against influenza virus proliferation in MDCK cells. The most potent extract obtained was from Muehlenbeckia hastulata (Polygonaceae), known as Quilo in Chile, from which three active principles were isolated and identified as pheophorbide a (1), hypericin (2) and protohypericin (3). Minimum inhibitory concentration (MIC) values of 42 ng/ml for compound 1, 2.

Regional differences in D/L aspartic acid ratios in the human mandible as a possible indicator of the bone remodeling rate.

In slowly metabolizing tissue such as tooth, bone and ocular lens, D-amino acids converted from L-amino acids accumulate with age and thus reflect the tissue turnover rate. To investigate whether D-amino acids play a role in determining the bone remodeling rate, we measured the accumulation of D-aspartic acid, which has the fastest rate of racemization, in various areas of the mandible. The level of D-aspartic acid was higher in the ramus than in the body (P < 0.

Right gonadal arteries passing dorsally to the inferior vena cava: embryological hypotheses.

The right gonadal artery (RGA) usually arises from the anterior wall of the abdominal aorta below the level of the renal arteries and veins, passes ventrally to the inferior vena cava (IVC), and then runs obliquely downward to reach the pelvic cavity. In this study, we observed 59 Japanese cadavers and found that in eight of them (13.6%), the RGA's passed dorsally to the IVC.

A rare case of inferior mesenteric artery arising from the superior mesenteric artery, with a review of the review of the literature.

Anatomical variations of the inferior mesenteric artery (IMA) are uncommon. Generally, the IMA is very stable, arises directly from the abdominal aorta at the level of the third lumbar vertebra. We describe here an extremely rare case in which the IMA arose from the superior mesenteric artery.

An anomalous case of the hepatic artery arising from the superior mesenteric artery.

In a stdudenet course of gross anatomy dissection at Kanagawa Dental College in 2006, we found an extremely rare case of the hepatic artery arising from the superior mesenteric artery of a 78-year-old Japanese male cadaver. This case belonged to type V in Adachi's classification of the celiac trunk and the superior mesenteric artery (1928). The gastro-splenic trunk and hepato-mesenteric trunk both arose from the abdominal aorta and the left gastric artery arose from the gastro-splenic trunk.

Morphological observation of the horseshoe kidney with special reference to the vascular system in 2 Japanese cadavers.

Two cases of the horseshoe kidney in Japanese cadaver were reported in this paper. The kidneys and their associated vessels in the retroperitoneal cavity were carefully examined, and the histological examination of the isthmus was performed. In Case 1, four arteries arose from the abdominal aorta.

Corrosion casts of convoluted testicular arteries in mice and rats.

The preparation of vascular corrosion casts enables us to observe the minute features of blood vessels. For mice and rats, reports on the macroscopical appearance of testicular arteries with the cast technique have been quite limited. Therefore, in the present study, we tried to prepare corrosion casts of such arteries in order to observe the three-dimensional structures in mice and rats.