Publications by authors named "Iida O"
Article Synopsis
- - Drug-eluting therapies, especially the Eluvia stent, have significantly reduced restenosis rates in treating peripheral artery disease, but concerns over aneurysm formation following their use are emerging.
- - An 80-year-old man developed a giant aneurysm 27 months after receiving the Eluvia stent for a blocked artery, which was identified through ultrasound and treated with endovascular-covered stents.
- - The presence of a 'low echoic area' near the stent is a common ultrasound finding after Eluvia implantation; while typically benign for two years, it can lead to serious complications like aneurysms due to factors such as overlapping stents and mechanical stress.
Purpose: To reveal the rate of 1-year freedom from restenosis and to determine the factors associated with the restenosis risk in femoropopliteal (FP) lesions treated with a Ranger drug-coated balloon (DCB) in real-world clinical settings.
Methods: This multicenter, prospective observational study enrolled 1131 patients and 1453 de novo or restenotic FP lesions (mean age=75±9 years; female=35.3%, mean lesion length=19.
Purpose: To evaluate the impact of intravascular ultrasound (IVUS)-evaluated tissue morphology on recurrence following drug-coated balloon (DCB) angioplasty for the treatment of femoropopliteal in-stent restenosis (FP-ISR).
Methods: This study was a single-center, retrospective, observational study. Study subjects were 65 FP-ISR lesions (mean lesion length: 165 ± 88 mm, occlusive restenosis: 25%) in 53 patients (age: 76 ± 8, diabetes mellitus: 66%) who underwent DCB angioplasty and whose IVUS data of tissue morphology were available.
Background: Clinical impact of inframalleolar (IM) angioplasty in patients with chronic limb-threatening ischemia (CLTI) is still controversial.
Methods And Results: This single-center, retrospective study included 168 patients with CLTI and tissue loss who underwent angioplasty for IM lesions. Angiographic follow up was performed at reintervention between April 2010 and December 2020.
Toward Effective EVT for ALI: A Paradigm Shift Like PCI for ACS.
JACC Cardiovasc Interv
October 2024
Background: Although mortality after acute coronary syndrome (ACS) has improved in the acute phase, cardiovascular events occur at a certain frequency in the chronic phase. A hospital lipid-lowering protocol (HLP) could be effective in providing optimal lipid-lowering therapy to improve long-term clinical outcomes after ACS.
Aims: This study investigated the impact of HLP on clinical outcomes in patients with ACS.
Primary Percutaneous Coronary Intervention (PCI) has significantly contributed to reducing the mortality of patients with ST-segment elevation myocardial infarction (STEMI) even in cardiogenic shock and is now the standard of care in most of Japanese institutions. The Task Force on Primary PCI of the Japanese Association of Cardiovascular Intervention and Therapeutics (CVIT) proposed an expert consensus document for the management of acute myocardial infarction (AMI) focusing on procedural aspects of primary PCI in 2018 and updated in 2022. Recently, the European Society of Cardiology (ESC) published the guidelines for the management of acute coronary syndrome in 2023.
View Article and Find Full Text PDFBackground: Although femoropopliteal-specific stents have durable patency, stent thrombosis (ST) may occur, which can lead to acute limb ischaemia (ALI).
Aims: We aimed to investigate the clinical features and outcomes of ALI caused by femoropopliteal ST in patients with lower extremity artery disease.
Methods: This multicentre retrospective study included 499 patients with ALI - of whom 108 patients had ALI caused by femoropopliteal ST (ST-ALI) and 391 patients had ALI caused by other aetiologies (de novo ALI) - who underwent treatment between September 2011 and March 2023.
Background: The introduction of radial-specific equipment has made transradial (TR) aortoiliac (AI) endovascular therapy (EVT) more convenient.
Objectives: The authors aimed to investigate the perioperative outcomes of the TR approach in patients undergoing AI EVT for symptomatic peripheral artery disease.
Methods: The COMFORT (Contemporary Strategy for Aortoiliac Intervention) registry was a prospective, multicenter, observational study enrolling patients with symptomatic peripheral artery disease undergoing AI EVT between January 2021 and June 2023.
Article Synopsis
- High-dose drug-coated balloons (HD-DCB) and polymer-based drug-eluting stents (PB-DES) are both treatments for femoropopliteal artery disease, showing favorable outcomes in clinical trials, but their comparative effectiveness was unclear.
- This study analyzed data from 2 large registries with 2470 patients, focusing on the 1-year restenosis rate as the primary endpoint, and additional outcomes like reocclusion rate and major adverse events as secondary endpoints.
- Results indicated that the 1-year restenosis rate was notably lower for the PB-DES group (16.0%) compared to the HD-DCB group (22.0%), but no significant differences were found in other clinical outcomes
Background: Cilostazol has reported effectiveness for preventing aspiration pneumonia in patients with ischemic stroke, but whether it is similarly beneficial for patients with chronic limb-threatening ischemia (CLTI) is unclear.
Methods And Results: This retrospective single-center study enrolled 1,368 CLTI patients treated with endovascular therapy (EVT). In the multivariate analysis, predictors for aspiration pneumonia were age (hazard ratio [HR] 1.
Purpose: Although endovascular therapy (EVT) is considered a vital strategy for treating infrapopliteal lesions in chronic limb-threatening ischemia (CLTI), the recurrence rate after EVT exceeds that after bypass surgery (BSX). The optimal approach for managing infrapopliteal lesion recurrence in patients with CLTI and unhealed ulcers remains uncertain. This study aimed to evaluate the clinical outcomes of repeat EVT and subsequent inframalleolar BSX for CLTI with infrapopliteal lesion recurrence.
View Article and Find Full Text PDFArticle Synopsis
- Rauvolfia serpentina roots are used in Southeast Asian herbal medicine for various ailments including snake bites, fever, hypertension, and dysentery.
- The study evaluated the content of key active ingredients (reserpine, ajmaline, and ajmalicine) in the roots processed using different methods on plants cultivated in Japan.
- Results showed that a 30-minute drum mixer washing method is efficient for root processing, and active ingredient content is consistent across different root sizes, indicating uniform quality of the crude drug.
Objective: This study aimed to determine the impact of infrapopliteal (IP) revascularisation establishing in line flow to the wound (IFW) on wound healing in chronic limb threatening ischaemia (CLTI), using a core laboratory assessment for wounds and in line flow.
Methods: The Wound directed Angiosome RevasculaRIsation apprOach to patients with cRitical limb iSchaemia (WARRIORS) multicentre observational study enrolled patients with CLTI with tissue loss undergoing IP revascularisation in Japan, with scheduled two year follow up. The primary outcome measure was complete wound healing, defined as achievement of complete epithelialisation of all wounds without major amputation.
Article Synopsis
- The study aimed to validate the Japanese below-the-knee (J-BTK) chronic total occlusion (CTO) score as a predictor for successful guidewire crossing (S-GC) in patients undergoing endovascular therapy.
- Conducted at 16 medical centers, the study included 751 BTK CTOs in 497 patients, categorizing them based on their S-GC outcomes using a scoring system that assesses factors like entry type, calcification, vessel diameter, CTO length, and target vessel outflow.
- Results showed that higher J-BTK CTO scores correlated with lower S-GC success rates, and a modified version of the score, which included points for de novo lesions, further improved prediction accuracy for the likelihood
Article Synopsis
- * Researchers assessed 77 lower limb arteries from 36 patients, utilizing detailed histological analysis to quantify calcification severity.
- * Results indicated significant correlations between HD status and increased calcification severity, particularly in below-the-knee lesions, highlighting the risks associated with HD.
Background: Although technological improvements in intravascular ultrasound (IVUS) may reduce technical failures in endovascular therapy (EVT), perioperative complications (POCs) associated with IVUS use may increase.
Aims: This study investigated the impact of IVUS on periprocedural outcomes in symptomatic lower-extremity artery disease (LEAD) patients undergoing EVT.
Methods: This study evaluated 28,088 symptomatic LEAD patients who underwent EVT between January 2021 and December 2021 using a prospective nationwide registry in Japan.
Background: Sirolimus-coated balloons (SCB) for the treatment of femoropopliteal (FP) lesions have not been systematically studied, but initial outcomes from early studies are promising.
Objectives: The authors sought to evaluate the safety and efficacy of the SELUTION SLR SCB, composed of proprietary microreservoir technology combining sirolimus and biodegradable polymer, when used to treat mild-to-moderate FP disease in a Japanese population.
Methods: This multicenter, prospective, single-arm study (SELUTION SFA JAPAN) enrolled 134 patients with FP disease.
Purpose: In the present trial, the 24-month safety and effectiveness of the TCD-17187 drug-coated balloon (DCB) for the treatment of atherosclerotic lesions in the superficial femoral artery (SFA) and proximal popliteal artery (PA) were evaluated in Japanese patients.
Methods: This was a prospective, multicenter, core laboratory-adjudicated, single-arm trial. From 2019 to 2020, 121 patients with symptomatic peripheral artery disease were enrolled.
Background And Aims: Patients undergoing revascularization for lower extremity arterial disease (LEAD) may face a higher risk of mortality than those with coronary artery disease (CAD). This study aimed to characterize the difference in mortality risk between patients undergoing revascularization for LEAD and CAD and identify associated factors.
Methods: The 1-year database of 10 754 patients undergoing revascularization for CAD (n = 6349) and LEAD (n = 4405) was analysed.
Background: The relationship between baseline yellow plaque (YP) and vascular response after stent implantation has not been fully investigated.
Methods: This was a sub-analysis of the Collaboration-1 study (multicenter, retrospective, observational study). A total of 88 lesions from 80 patients with chronic coronary syndrome who underwent percutaneous coronary intervention were analyzed.