Publications by authors named "Ihsan K Jasim"
Diseases or defects of the skeleton are hazardous because of their specificity and intricacy. Bone tissue engineering has become an important area of research that offers promising new tools for making biomimetic hydrogels that can be used to treat bone diseases. New hydrogels with a distinctive 3D network structure, high water content, and functional capabilities are ranked among the most promising candidates for bone tissue engineering.
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- Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a survival rate under 10%, largely driven by the activity of the transcription factor STAT3, which promotes cancer cell survival and invasiveness.
- The regulation of STAT3 by interleukin 28 receptor α (IL28RA) and glutathione s-transferase mu-3 (GSTM3) further enhances its role in cell proliferation and metastatic behavior in PDAC.
- Recent developments in the form of a selective STAT3 inhibitor, known as N4, show promising effectiveness against PDAC, highlighting its potential as a therapeutic target.