Double Core-Shell Semiconducting Molecular Chain Halogen-Bridged Metal Complexes with Ohmic Contact Heterojunctions.

The fabrication of heterostructures from low-dimensional materials is very challenging, particularly the creation of low-dimensional heterojunctions that can be characterized at an atomic resolution. In a previous work, a two-dimensional (2D) heterostructure made from halogen-bridged metal complexes (MX-Chains), [Ni(chxn)Br]Br (chxn = 1,2-diaminocyclohexane) and [Pd(chxn)Br]Br, has been synthesized, and the nature of the electronically 1D heterojunction at an atomic resolution was revealed. In the work reported here, we have successfully fabricated double core-shell crystals (Ni-Pd-Ni) from these MX-Chains, using a stepwise electrochemical epitaxial method.

Diruthenium(II,II) Complex Assemblies Showing Electrical Conduction via π-Stacked 2-Pyrenecarboxylate Moiety.

Through-space electrical conduction in paddlewheel-type homovalent dinuclear complexes remains poorly understood, despite the numerous reports on these complexes. Herein, the electrical conduction of new Ru(II,II) complexes with 2-pyrenecarboxylate (pyrCOO) ligands, [Ru(pyrCOO)X] ⋅ n(X) (where X=DMF (Ru-DMF), NMP (Ru-NMP), DMA (Ru-DMA)), was investigated. The dimensionality of π-stacking interactions between discrete molecules in Ru-DMA is higher (two-dimensional) than in Ru-DMF and Ru-NMP (stair-like one-dimensional).

Hydrogen isotope separation at exceptionally high temperature using an unsaturated organometallic complex.

A new approach for hydrogen isotope separation using an unsaturated organometallic complex was proposed. Adsorption measurements of [Mn(dppe)(CO)(N)](BArF) (Mn-dppe) (dppe = 1,2-bis(diphenylphosphino)ethane, BArF = B[CH(3,5-CF)]) using H and D revealed a significant difference in the adsorption enthalpy of H/D at much higher room temperatures than in previous studies, with D molecules being more strongly adsorbed on unsaturated metal sites. Mixed gas adsorption isotherms were calculated at each temperature using IAST, and it was predicted that D uptake was much larger than H uptake.

Can FDG-PET after neoadjuvant chemotherapy plus nivolumab predict residual disease in non-small cell lung cancer?

Neoadjuvant therapy with nivolumab improves event-free survival (EFS) in patients with resectable non-small cell lung cancer, and a pathological complete response is a predictor of longer EFS. We assessed metabolic responses using 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) before and after neoadjuvant treatment to explore its surrogacy for pathological complete response (pCR). We describe three patients with squamous cell lung carcinoma who underwent neoadjuvant therapy with nivolumab plus chemotherapy, followed by surgery.

An n-type semiconducting diazaporphyrin-based hydrogen-bonded organic framework.

Significant effort has been devoted to the development of materials that combine high electrical conductivity and permanent porosity. This paper discloses a diazaporphyrin-based hydrogen-bonded organic framework (HOF) with porosity and n-type semiconductivity. A 5,15-diazaporphyrin Ni(ii) complex with carboxyphenyl groups at the positions afforded a HOF due to hydrogen-bonding interactions between the carboxy groups and -nitrogen atoms.

Calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons.

The Ca-dependent activator protein for secretion (CAPS/CADPS) family protein facilitates catecholamine release through the dense-core vesicle exocytosis in model neuroendocrine cell lines. However, it remains unclear if it induces dopamine release in the central neurons. This study aimed to examine the expression and function of CADPS2, one of the two CADPS paralogs, in dopamine neurons of the mouse midbrain.

Neoadjuvant nivolumab plus chemotherapy followed by resection for superior sulcus tumour with high PD-L1 expression: A case report.

The standard treatment for resectable non-small cell lung cancer (NSCLC) located in the superior sulcus is neoadjuvant chemoradiotherapy followed by highly invasive resection. Based on the results of the CheckMate 816 trial, which showed a marked improvement in the efficacy of neoadjuvant chemo-immunotherapy, we report a case of minimally invasive resection after neoadjuvant nivolumab plus chemotherapy for superior sulcus NSCLC, resulting in a pathologic complete response. The patient was a 76-year-old man with a 65-mm right superior sulcus tumour diagnosed as squamous cell carcinoma with 95% PD-L1.

Enhanced hydrogen uptake of dihydrogen complex porous materials support.

This research focuses on enhancing H adsorption by using the [Mo(PCy)(CO)] complex supported on porous materials such as silica gel and mesoporous carbon. The study reports a significant increase in hydrogen adsorption capacity, reaching up to 9.3 times that of the bulk complex.

Minute pulmonary meningothelial-like nodule that was difficult to differentiate from lung adenocarcinoma due to specific computed tomography findings changes: A case report.

Minute pulmonary meningothelial-like nodules (MPMNs) are benign lesions characterized by the appearance of ground-glass nodules (GGN) on computed tomography (CT). In the present case, an MPMN gradually developed into a substantial component during chest CT follow-up, and the GGN gradually transformed into a part-solid nodule. The imaging course described in this case is quite unique.

Administered dosage and effective dose estimated from 81Rb-rubidium hydroxide for lung ventilation scintigraphy using 81mKr noble gas.

The aim of this study was to estimate the administered dosage of 81mKr noble gas as calculated by the radioactivity of 81Rb-rubidium hydroxide (81RbOH). The administered dosage was regarded as the total amount of 81mKr noble gas. The radioactivity of 81mKr was calculated using the radioactivity of 81RbOH at the examination, the beginning of inhalation, the inhalation duration and the attenuation volume from the generator to the patient for 81mKr noble gas.

Efficacy of Continuous Saline Irrigation Therapy for Descending Necrotizing Mediastinitis.

 Descending necrotizing mediastinitis (DNM) is a poor prognosis disease. This study aims to examine the patient background and treatment of DNM and to identify more effective treatments for DNM.  The patient background and treatment of 11 patients who underwent surgery for DNM between November 2010 and June 2021 were studied.

Efficacy and safety of bone management agents administered at 12 weeks vs. 4 weeks in patients with bone metastases: A systematic review.

Background: Bone modifying agents (BMAs) have been used to prevent skeletal-related events (SRE) in cancer patients with bone metastases. In this meta-analysis, efficacy and adverse events (AEs) were studied based on a de-escalation strategy in which the BMA dosing interval was prolonged from 4 to 12 weeks.

Methods: PubMed, Cochrane, ICHUSHI, and CINAHL were searched for articles on BMA dosing intervals from outcomes measured were the incidence of SRE and related various AEs.

Size control of induced pluripotent stem cells colonies in two-dimensional culture for differentiation into functional monocyte-like cells.

Background Aims: Monocytes, derived from hematopoietic stem cells (HSCs), play a pivotal role in the immune response to cancer. Although they are an attractive source of cell therapy for cancer, a method for ex vivo expansion has not yet been established. Monocytes differentiated from pluripotent stem cells (PSCs), including induced pluripotent stem cells (iPSCs), can be an alternative source of HSC-derived monocytes because of their self-renewal and pluripotency.

Hexagonal crystalline Magnus' green salt analogues prepared from hydroxy-functionalised Pt and Pd complexes.

New Magnus' green salt (MGS) analogues, [M(dabdOH)][MCl]·2HO (dabdOH = (2,3)-2,3-diaminobutane-1,4-diol; M = Pd (1) and M = Pt(2)), in which [M(dabdOH)] and [MCl] are stacked alternately to form linear chains, were obtained as hexagonal plate crystals. The hexagonal shape and large crystal size are unprecedented features as MGS analogues. An unusual trigonal grade separation of chain complexes has been revealed by the structural analysis.

Sclerosing Fibroadenoma With Atypical Ductal Hyperplasia Mimicking Invasive Carcinoma: A Case Report With Diagnostic Pitfall.

Fibroadenoma (FA) of the breast is a benign fibroepithelial lesion rarely showing atypical epithelial overgrowth. We present the case of a 50-year-old Japanese woman with sclerotic FA with atypical ductal hyperplasia (ADH)/ductal carcinoma in situ (DCIS). A small mass was detected during clinical examination in the upper lateral area of the left breast.

Single-Crystal Structures of Benzenehexathiol and Its Disulfide Forms.

Oligothiols are useful as building blocks in the construction of disulfide-based macrocycles and polymers or as ligands for coordination polymers. Above all, benzenehexathiol () is a particularly important molecule, as it is used to construct conductive two-dimensional MOFs. Despite the desire to clarify its structure and isolate it to high purity, the chemical instability of has hampered single-crystal X-ray structure analysis of intact .

Improved Production of Induced Pluripotent Stem Cells Using Dot Pattern Culture Plates.

The rate of cell proliferation is a crucial factor in cell production under good manufacturing practice (GMP) control. In this study, we identified a culture system for induced pluripotent cells (iPSCs) that supports cell proliferation and viability and maintains the cells in an undifferentiated state even at 8 days after seeding. This system involves the use of dot pattern culture plates that have been coated with a chemically defined scaffold which has high biocompatibility.

Hypercalcemia in metastatic parathyroid carcinoma followed by hypocalcemia after resection: A case report.

A 72-year-old man was diagnosed with hypercalcaemia 13 years ago. He was diagnosed with hyperparathyroidism associated with a parathyroid tumour and surgery was performed. Postoperatively, his serum calcium levels, which had once normalized, rose again.

Usefulness of preset count acquisition in pediatric Tc-DMSA planar imaging.

Objective: This study was aimed at determining the minimum acquisition count to provide diagnosable image quality (DIQ) and investigating the usefulness of preset count acquisition (PCA) for planar images of pediatric Tc-dimercaptosuccinic acid (DMSA) scintigraphy.

Methods: First, we calculated a coefficient of variation (CV) for DIQ with the shortest acquisition time through visual evaluation in 12 pediatric patients who underwent Tc-DMSA scintigraphy. Second, a minimum acquisition count to achieve the CV for DIQ was determined with the single regression analysis using CV as an explanatory variable and the total acquisition count as an objective variable in 81 pediatric patients.

Beyond the Conventional Limitation of Photocycloaddition Reaction in the Roomy Nanospace of a Metal-Organic Framework.

Topochemical reactions provide selective products based on the molecular position; however, they generally require molecules to be placed in strictly limited orientations and distances, making them less versatile. In this study, we found that by confining -4-styrylpyridine (4-spy) as a reactive substrate in a flexible metal-organic framework (MOF) nanospace, [2+2] cycloadducts can be selectively obtained, even when the distance between two C═C bonds of 4-spy in the crystal is 5.9 Å, which is much larger than the conventionally observed upper limit (4.

Quinoid-Based Three-Dimensional Metal-Organic Framework Fe(dhbq): Porosity, Electrical Conductivity, and Solid-State Redox Properties.

We report the synthesis, characterization, and electronic properties of the quinoid-based three-dimensional metal-organic framework [Fe(dhbq)]. The MOF was synthesized without using cations as a template, unlike other reported Xdhbq-based coordination polymers, and the crystal structure was determined by using single-crystal X-ray diffraction. The crystal structure was entirely different from the other reported [Fe(Xdhbq)]; three independent 3D polymers were interpenetrated to give the overall structure.

Creation of single molecular conjugates of metal-organic cages and DNA.

Here we report the development of an equimolar conjugate of a metal-organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system.

Deprotonation-Induced Color Modulation in N,N'-Dihydroxynaphthalenediimide-Based Organic Crystals.

N,N'-dihydroxy-1,4,5,8-naphthalenetetracarboxdiimide (NDI-(OH) ) has attracted much attention in recent years, because its doubly deprotonated state, (O-NDI-O) , has metal-coordination ability and characteristic electronic transition useful for designing electronic and optical functions. In contrast, a molecular crystal with the mono-deprotonated (HO-NDI-O) ion remains unknown. We herein report an organic crystal containing non-disproportionated (HO-NDI-O) ions, which are connected by very strong O-H-O hydrogen bonds.

Relationship between postoperative atrial fibrillation and its recurrence after lung resection.

Purpose: Atrial fibrillation (AF) frequently occurs after pulmonary resection and is commonly referred to as postoperative atrial fibrillation (POAF). This study explored whether or not POAF is related to the recurrence of AF in the chronic phase.

Methods: A total of 1311 consecutive patients without a history of AF who underwent lung resection based on a diagnosis of lung tumor were retrospectively analyzed.