Physiological Responses Associated with Nordic-Walking and Walking in Middle-age Women.

This study aimed to analyze the influence of supervised 12-week walking (W) and Nordic-walking (NW) programs on changes in specific physiological parameters in middle-aged women 55.40±7.87 and 52.

Changes in Health-related Parameters Associated with Sports Performance Enhancement Drugs.

The purpose of this study was to evaluate changes in health-related parameters caused by the administration of anabolic-androgenic steroids and "fat-burning drugs" during a 6-month competition preparation period. The physiological, biochemical, and anthropometric parameters studied included serum cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, aspartate aminotransferase, alanine transaminase, bilirubin, body mass, and percentage of total body fat. Changes in the parameters studied were analyzed at monthly intervals during six months of preparation for competition.

Age-dependent changes in fat- and water-soluble vitamins-National Health and Nutrition Examination Surveys study.

Aging is an independent risk factor for the development of various diseases associated, among others, with detrimental blood levels of fat- and water-soluble vitamins. Thus, the objective of this study is to investigate age-related changes in blood levels of vitamin A, B12, C, D, and E. Subject serum vitamin levels were obtained from the combined National Health and Nutrition Examination Surveys (NHANES).

Physiological Responses Associated with Nordic-walking training in Systolic Hypertensive Postmenopausal Women.

Loss of physical strength and hypertension are among the most pronounced detrimental factors accompanying aging. The aim of this study was to evaluate the influence of a supervised 8-week Nordic-walking training program on systolic blood pressure in systolic-hypertensive postmenopausal women. This study was a randomized control trial on a sample of 24 subjects who did not take any hypertension medications.

Supplementation with Silk Amino Acids improves physiological parameters defining stamina in elite fin-swimmers.

Background: Previous animal study has shown that supplementation with silk amino acid hydrolysate (SAA) increases stamina in mice. The presented study was the first formal evaluation of the influence of SAA supplementation on parameters defining physiological fitness level in humans.

Methods: It was a randomized controlled trial with a parallel-group design on elite male fin-swimmers.

Effect of a MAST Exercise Program on Anthropometric Parameters, Physical Fitness, and Serum Lipid Levels in Obese Postmenopausal Women.

The purpose of this study was to examine an influence of a mixed aerobic and strength training program (MAST) on anthropometry, serum lipid levels, physical performance, and functional fitness in obese postmenopausal women. The MAST sessions were held three times per week, and the exercise program lasted for 10 weeks. The exercise group demonstrated a statistically significant improvement in maximal oxygen uptake, a waist/hip ratio, and strength of the upper and lower body.

Proteome changes in response to ecologically viable environmental variation in Calanus sinicus.

Copepods are the most abundant multicellular animal group and are often most important component of zooplankton and indicators of local and global climate change. Among this broad group of animals, Calanus sinicus holds an important role in the ecosystems of The East China Sea, The Korea Strait, and The East Sea. By comparing the response of their proteomes to ecologically viable environment changes, this study tried to identify molecular responses accountable for compensation of a change in metabolic rates.

Age- and menopause-related differences in physiological factors of health quality in women aged 35-60.

The purpose of this study was to elucidate using time series analysis age and menopause induced differences in selected health quality related physiological factors. The study was conducted, using the Third National Health and Nutrition Examination Survey (NHANES III), and the NHANES 1999-2002 data, on women aged 35-60. Subjects who had not had surgical menopause, did not use contraceptives, did not smoke, and did not breastfeed during the examination, and did not use contraception and for whom follicle stimulating hormone and luteinizing hormone (LH) activity was assessed, were included in the study.

The changes of the specific physiological parameters in response to 12-week individualized training of young soccer players.

The aim of this study was to analyze the influence of individualized training (IT) as a function of motor type and effort status on changes of in specific physiological parameters among young soccer competitors. Blood pH and lactate concentrations, and lactate dehydrogenase (LDH), and creatine kinase (CK) activities were measured at the beginning of a preparation period, a match season, and a recuperation period of a 6-month macrocycle. The differences among specific physiological parameters as a function of the preparation phase for a defined motor type were analyzed by means of a 1-way generalized linear model (GLM) for repeated measurements.

Measures of menopause driven differences in levels of blood lipids, follicle-stimulating hormone, and luteinizing hormone in women aged 35 to 60 years: National Health and Nutrition Examination Survey III and National Health and Nutrition Examination Survey 1999-2002 study.

Objective: The purpose of this cross-sectional study was to assess the association of the menopausal transition with differences in lipid and endogenous hormone levels in normal [18.5 kg/m² ≤ body mass index (BMI) ≤ 24.99 kg/m] and overweight (BMI >24.

The changes of bone mineral density in relation to body mass index and aging among Polish and different ethnic women in the United States: cross-sectional studies.

In the present study, we analyzed the changes of bone mineral density (BMD) among Polish women age 40-79, as a function of biological aging and body mass index (BMI) class, and compared them with the US sample (National Health and Nutrition Examination Survey III). The null hypothesis of this study was that the rate of BMD change is femoral region, age, ethnicity, and BMI dependent. The studied group was divided into 4 age decades: 40-49, 50-59, 60-69, and 70-79 and 2 BMI classes (normal: 18.

Influence of individualized training on psychomotor performance of young soccer players.

The aim of this study was to analyze the influence of individualized training (IT) on psychomotor performance of young soccer players. Psychomotor performance was measured by means of differential response time and number of correct responses to audio and visual stimuli. Kinematic analysis allowing assessment of both the distances and the average speeds of young players during consecutive matches was also performed.

The age-dependent divergence of strength and coordinating parameters among men and women: the cross-sectional studies.

The objective of these studies was to determine the gender-dependent changes of coordination and fitness parameters in function of age by means of observational, cross-sectional study. We studied 180 male and 180 female participants by means of flamingo, kinesthetic differentiation, spatial orientation, reaction to signals, arm bend and chair stand tests. Generalized linear model (GLM) and the Welch test and the appropriate t-tests were used to compare the differences between the studied age groups.

Changes in level of VO2max, blood lipids, and waist circumference in the response to moderate endurance training as a function of ovarian aging.

Objective: The aim of this study was to analyze the influence of moderate endurance training on a set of physiological parameters accompanying menopausal transition.

Methods: One hundred sixty-eight women participated in the study. The cohort was divided into three subgroups: premenopausal, perimenopausal, and postmenopausal.

Deterioration of basic coordinative parameters defines life quality of elderly.

The objective of the studies was to analyze the level of deterioration of basic coordinative parameters and to derive the present correlation. 180 female participants with no neurological disorders and limb surgery were studied by means of flamingo, kinesthetic differentiation, spatial orientation and reaction to signals tests. t-test for un-paired data and Pearson correlation analyses were performed.

The primary study on influence of fitness camps on rehabilitation efficiency of full laryngectomy patients.

The objective of this study was to estimate the efficiency of exercise driven rehabilitation procedure after laryngectomy. A retrospective review of case notes from the Ludwig Rydygier Hospital, Bydgoszcz, Poland archives was performed. The setting was the Rehabilitation Unit in Department of Occupational Therapy and Rehabilitation of Collegium Medicum, Nicolas Copernicus University, Poland.

Correlations between postural stability and strength of lower body extremities of women population living in long-term care facilities.

The present study was aimed at analyzing correlation between strength of lower body extremities and postural stability in function of age. A pool of 180 women divided into 6 age groups (65-69, 70-74, 75-79, 80-84, 85-89 and 90-94 years) was examined. They all were informed-consent participants.

The studies on substrate, product and inhibitor binding to a wild-type and neuronopathic form of human acid-beta-glucosidase.

Gaucher disease is a lysosomal storage disorder caused by deficiency of human acid beta-glucosidase. Recent x-ray structural elucidation of the enzyme alone and in the presence of its inhibitor was done, which provided an excellent template for further studies on the binding of substrate, product and inhibitor. To draw correlations between the clinical manifestation of the disease driven by point mutations, L444P and L444R, and the placement and function of putative S-binding sites, the presented theoretical studies were undertaken, which comprised of molecular dynamics and molecular docking methods.

2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells.

Targeted differentiation of neural progenitor cells (NPCs) is a challenge for treatment of neurodegenerative diseases by cell replacement therapy and cell signalling manipulation. Here, we applied a proteome profiling approach to the rat striatal progenitor model cell line ST14A in order to elucidate cellular differentiation processes. Native cells and cells transfected with the glial cell line-derived neurotrophic factor (GDNF) gene were investigated at the proliferative state and at seven time points up to 72 h after induction of differentiation.

2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM).

The proteome of a proliferating human stem cell line was analyzed and then utilized to detect stem cell differentiation-associated changes in the protein profile. The analysis was conducted with a stable human fetal midbrain stem cell line (ReNcell VM) that displays the properties of a neural stem cell. Therefore, acquisition of proteomic data should be representative of cultured human neural stem cells (hNSCs) in general.

NMR detection of intermolecular NH.OP hydrogen bonds between guanidinium protons and bisposphonate moieties in an artificial arginine receptor.

Hydrogen bonding plays a major role in the selective recognition of guanidinium groups by receptor molecules. The present NMR investigation provides direct experimental evidence of hydrogen bonds in an artificial arginine receptor complex consisting of alpha-N-benzoylarginine ethyl ester and a bisphosphonate tweezers molecule. trans-Hydrogen bond 2hJHP couplings between the phosphonate moieties and individual guanidinium protons as well as the amide proton have been detected by [1H,31P]-HMBC and [31P,1H]-INEPT experiments.

Analysis of the products of genes encompassed by the theoretically predicted pathogenicity islands of Mycobacterium tuberculosis and Mycobacterium bovis.

Sequencing of the genomes of Mycobacterium tuberculosis and Mycobacterium bovis provides a unique opportunity to study the biology of these pathogens on the genomic level. The computational detection of anomalous gene clusters such as those encompassed by pathogenicity islands allows for a narrowing of the study into well-defined groups of genes. Pathogenicity islands of M.

Homology modeling and molecular dynamics study of NAD-dependent glycerol-3-phosphate dehydrogenase from Trypanosoma brucei rhodesiense, a potential target enzyme for anti-sleeping sickness drug development.

Sleeping sickness and Chagas disease are among the most severe diseases in Africa as well as Latin America. These two diseases are caused by Trypanosoma spp. Recently, an enzyme of a glycolytic pathway, NAD-dependent glycerol-3-phosphate dehydrogenase, of Leishmania mexicana was crystallized and its structure determined by x-ray crystallography.