Publications by authors named "Igor V F Dos Santos"
Rational Approach to New Chemical Entities with Antiproliferative Activity on Ab1 Tyrosine Kinase Encoded by the Gene: An Hierarchical Biochemoinformatics Analysis.
Pharmaceuticals (Basel)
November 2024
Article Synopsis
- - The study involved screening around 2.5 million compounds from various databases to identify potential inhibitors of a chimeric tyrosine kinase, focusing on their antiproliferative activity and pharmacokinetic properties.
- - Nine compounds were identified as having desirable ADME/Tox properties, with their biological activity predictions indicating that they could be effective protein kinase inhibitors, showing varied activity percentages.
- - Two promising compounds, LMQC01 and LMQC04, demonstrated strong molecular docking results and stability in simulations, suggesting they have good potential for inhibiting the enzyme function of the target kinase and are easy to synthesize.
Ethyl Acetate Fraction of and Its Component Ellagic Acid Exert Antibacterial and Anti-Inflammatory Properties against subsp. .
Antibiotics (Basel)
June 2022
subsp. () causes chronic infections, which has led to the need for new antimycobacterial agents. In this study, we investigated the antimycobacterial and anti-inflammatory activities of the ethyl acetate fraction of leaves (BoEA) and ellagic acid (ElAc).
View Article and Find Full Text PDFSkin Cancer (SC) is among the most common type of cancers worldwide. The search for SC therapeutics using molecular modeling strategies as well as considering natural plant-derived products seems to be a promising strategy. The phytochemical Rocaglamide A (Roc-A) and its derivatives rise as an interesting set of reference compounds due to their cytotoxic activity with SC cell lines.
View Article and Find Full Text PDFStudy of the non-clinical healing activities of the extract and gel of Portulaca pilosa L. in skin wounds in wistar rats: A preliminary study.
Biomed Pharmacother
December 2017
Introduction: Portulaca pilosa L., belonging to the family Portulacaceae, is a common herbaceous plant in the Americas and in the Amazon, is popularly known as love-grown and is traditionally used as an aid in the treatment of burns, buds, insect bites and wound healing. This study aims to evaluate the non-clinical topical healing activity of the P.
View Article and Find Full Text PDFZebrafish is an excellent model organism for studying tissue alterations caused by Bothrops alternatus venom (BAV) and for screening new anti-venom drugs. To study tissue alterations following exposure to BAV and the roles that glucocorticoids play in these tissue reactions, zebrafish were randomly divided into five groups: the free injection control group (FIC), the phosphate-buffered saline injection control group (PIC), the venom injected group (VI), the group treated with dexamethasone 1 h before venom injection (D1hBVI) and the group treated with dexamethasone 1 h after venom injection (D1hAVI). The concentration of BAV injected was 0.
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