Publications by authors named "Igor Snitcovsky"
Valproic acid combined with cisplatin-based chemoradiation in locally advanced head and neck squamous cell carcinoma patients and associated biomarkers.
Milena Perez Mak Fatima Solange Pasini Lixia Diao Fabyane O Teixeira Garcia Tiago Kenji Takahashi Igor Moysés Longo Snitcovsky
Ecancermedicalscience
December 2020
Article Synopsis
- - The study aimed to assess the effectiveness of combining valproic acid (VPA) with cisplatin-based chemoradiation (CCRT) in treating patients with locally advanced head and neck cancer, focusing on response rate (RR) and associated biomarkers.
- - Although early results showed a high RR of 88% in evaluable patients, the trial faced significant toxicities, leading to its premature termination after just ten participants.
- - Analysis revealed distinct differences in microRNA expression between patients and healthy controls, with lower levels of tumor suppressor microRNAs, and a specific HDAC2 H-score potentially indicating lengthy disease-free survival.
Article Synopsis
- The TNM classification system, used for diagnosing gastric adenocarcinoma, is limited in predicting patient outcomes, highlighting the need for molecular insights to improve prognosis and identify new treatment targets.
- Researchers analyzed 51 tumor samples from gastric cancer patients to identify genes linked to prognosis, focusing on those with poor (less than 24 months) versus favorable (24 months or more) survival rates.
- They identified a gene trio (OLR1, CXCL11, and ADAMDEC1) as independent prognostic markers and observed that a dysfunctional inflammatory response in tumors correlates with a worse prognosis.
Article Synopsis
- Researchers found that specific gene expressions in oral squamous cell carcinoma (OSCC) tumors can predict whether lymph nodes are compromised, which helps in determining treatment strategies.
- They identified four key genes using techniques like RT-PCR to build a "Nodal Index" (NI) based on their expression in tumors from two patient groups, effectively distinguishing between lymph node positive and negative cases.
- The Nodal Index showed high accuracy—88.6% in a learning group and 80% in an independent validation group—indicating its potential as a reliable tool for predicting lymph node metastasis in OSCC patients, regardless of tumor size and grade.
Article Synopsis
- The study aims to enhance the predictive models for how breast cancer patients respond to neoadjuvant chemotherapy by analyzing tumor gene expression profiles using cDNA microarray technology.
- The authors reviewed 279 relevant publications, noting a rising trend in research on this topic, particularly in the use of microarray platforms to gather extensive data from various studies.
- The findings suggest that identifying specific gene signatures can help tailor chemotherapy treatments, providing better outcomes for patients who may be resistant to certain chemotherapeutic agents.
ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation.
Gilberto De Castro Fatima Solange Pasini Sheila Aparecida Coelho Siqueira Alberto Rossetti Ferraz Rosangela Correa Villar Igor Moysés Longo Snitcovsky
Oncol Rep
March 2011
Article Synopsis
- Adjuvant cisplatin-based chemoradiation significantly improves survival rates for head and neck squamous cell carcinoma (HNSCC) patients with risk features.
- The study focused on ERCC1 (excision repair cross-complementation group 1) as a potential marker for prognosis, assessing ERCC1 protein and mRNA expression alongside the T19007C polymorphism.
- Results indicated that higher ERCC1 protein and mRNA levels were associated with better 5-year overall survival rates, suggesting that ERCC1 expression could be an important prognostic factor for HNSCC patients undergoing treatment.
Oral mucositis prevention by low-level laser therapy in head-and-neck cancer patients undergoing concurrent chemoradiotherapy: a phase III randomized study.
Aline Gouvêa de Lima Rosângela Correa Villar Gilberto de Castro Reynaldo Antequera Erlon Gil Igor Moisés Longo Snitcovsky
Int J Radiat Oncol Biol Phys
January 2012
Purpose: Oral mucositis is a major complication of concurrent chemoradiotherapy (CRT) in head-and-neck cancer patients. Low-level laser (LLL) therapy is a promising preventive therapy. We aimed to evaluate the efficacy of LLL therapy to decrease severe oral mucositis and its effect on RT interruptions.
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- The study aimed to determine if the levels of Smad1-8 mRNAs could predict survival in patients with oral squamous cell carcinoma (SCC).
- Researchers analyzed mRNA expression in 48 oral SCC cases and other related cancers, finding that high Smad6 and low Smad2 expressions were linked to better survival outcomes.
- The results indicate that Smad6 and Smad2 could serve as independent prognostic factors for oral SCC, suggesting the need for further investigation into the role of TGFbeta signaling in this context.
Article Synopsis
- * Pretreatment OPN levels were found to be higher in patients with more advanced disease stages, and lower OPN levels were linked to better treatment responses.
- * High pretreatment OPN levels correlated with shorter survival times, suggesting that OPN could serve as a prognostic marker in HNSCC treatment strategies.
High-dose cisplatin concurrent to conventionally delivered radiotherapy is associated with unacceptable toxicity in unresectable, non-metastatic stage IV head and neck squamous cell carcinoma.
Gilberto de Castro Igor Moisés Longo Snitcovsky Eloísa Maria Mello Santiago Gebrim Glauber Moreira Leitão Wladimir Nadalin
Eur Arch Otorhinolaryngol
December 2007
Article Synopsis
- - Unresectable head and neck squamous cell carcinoma (HNSCC) includes a diverse group of patients, specifically in stages III and IV, and this study investigated the feasibility of a specific treatment regime involving cisplatin and radiotherapy for stage IV patients.
- - A total of 30 patients participated in the study, where they received a combination of 70 Gy radiation and cisplatin, resulting in an overall response rate of 60%, with some patients achieving complete or partial tumor responses.
- - The treatment was associated with significant side effects, including toxicities affecting 26 patients and three deaths, with median progression-free survival of 8 months and overall survival of 17.3 months noted, indicating challenges in administering
Purpose: This study was designed to identify genes that could predict response to doxorubicin-based primary chemotherapy in breast cancer patients.
Experimental Design: Biopsy samples were obtained before primary treatment with doxorubicin and cyclophosphamide. RNA was extracted and amplified and gene expression was analyzed using cDNA microarrays.
Article Synopsis
- HC11 cells are a type of mouse mammary cell that stay normal, while HC11 ras cells, which have been transformed with the H-ras gene, can cause tumors.
- The study found that HC11 ras cells have less Vitamin D receptor (VDR) mRNA, but this is not because of differences in how the gene is transcribed.
- Instead, the lower VDR mRNA levels in HC11 ras cells are likely due to increased degradation after transcription, and blocking the ras pathway can restore VDR mRNA levels.
Article Synopsis
- - The study focused on how 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) affects cell proliferation by analyzing gene expression in a normal murine mammary epithelial cell line (HC11) and found specific genes like c-jun and fra-2 were up-regulated.
- - Changes in various cyclin levels were observed, including a reduction in cyclin C and slight increases in cyclins A2 and E, while several others, including TGF beta transcripts, remained unaffected.
- - The findings suggest that the antiproliferative effects of 1,25(OH)(2)D(3) are linked to the increase in proteins