Probe-based confocal laser endomicroscopy in the diagnosis of diffuse cystic lung disease in Sjögren's syndrome.

Sjögren's syndrome is a systemic autoimmune disease characterized by lymphocytic infiltration of various organs with a wide frequency of pulmonary involvement. Diffuse cystic lung disease in Sjögren's syndrome is a rare condition and requires differential diagnosis with other cystic pathologies such as lymphangioleyomiomatosis or Langerhans cell histiocytosis. Probe-based confocal laser endomicroscopy (pCLE) is a method of in vivo investigation of airways and lung tissue at a microscopic level during bronchoscopy.

Probe-based confocal laser endomicroscopy in COVID-19.

Probe-based confocal laser endomicroscopy (pCLE) is a method that produces microscopic imaging of a lung tissue during bronchoscopy. We report a case ot a patient with negative nasopharyngeal swabs and suspected lung cancer who underwent pCLE. The diagnosis of COVID-19 was confirmed by PCR analyses of lavage fluid and transbrohial biopsy.