Publications by authors named "Igor Pavlovich Yakovlev"
Drug Res (Stuttg)
January 2022
Article Synopsis
- - A highly sensitive HPLC-ESI/MS method was developed for accurately measuring a new antifungal drug, TDZ, using a simplified extraction process from plasma and urine samples.
- - The method utilized reversed-phase HPLC with a specific column and mobile phase, allowing for effective separation and detection of TDZ with a strong linear response (R=0.999) across two concentration ranges.
- - This technique was validated with low matrix effects and high recovery rates, and it was successfully used to evaluate the drug's pharmacokinetic parameters after intravenous and oral administration in rats.
