Publications by authors named "Igor Mrdjen"
Use of three topical antiseptic compounds-benzalkonium chloride (BAC), benzethonium chloride (BZT), and chloroxylenol (PCMX)-has recently increased because of the phaseout of other antimicrobial ingredients (such as triclosan) in soaps and other disinfecting and sanitizing products. Further, use of sanitizing products in general increased during the coronavirus (COVID-19) pandemic. We assessed the environmental safety of BAC, BZT, and PCMX based on best available environmental fate and effects data from the scientific literature and privately held sources.
View Article and Find Full Text PDFExposure to cyanobacterial hepatotoxins has been linked to the promotion and increased incidence of liver cancer in pre-clinical and epidemiologic studies. The family of hepatotoxins, microcystins (MCs), are produced by over 40 cyanobacterial species found in harmful algal blooms (HABs) worldwide, with MC-LR being the most common and potent MC congener. In the current study, we hypothesized that the low-dose chronic ingestion of Microcystis cyanotoxins via drinking water would promote liver carcinogenesis in pre-initiated mice.
View Article and Find Full Text PDFMicrocystis toxin-mediated tumor promotion and toxicity lead to shifts in mouse gut microbiome.
Ecotoxicol Environ Saf
December 2020
Microcystins (MCs) are the most prevalent cyanotoxins reported in freshwater. While numerous studies have examined the toxicological impacts of MCs on mammalian systems, very few have examined the chronic impacts of MCs on the gut microbiome of exposed organisms. Our understanding of the relationship of MCs, especially lysed toxic cyanobacteria, and the gut microbiota is very limited.
View Article and Find Full Text PDFMicrocystin (MC) exposure is an increasing concern because more geographical locations are covered with cyanobacterial blooms as eutrophication and bloom-favoring environmental factors become more prevalent worldwide. Acute MC exposure has been linked to gastrointestinal distress, liver toxicity, and death in extreme circumstances. The goal of this study was to provide an accurate and comprehensive description of MC-LRs impacts on liver pathology, clinical chemistry, and gap junction intercellular communication (GJIC) in CD-1 male and female mice.
View Article and Find Full Text PDFSimple and practical on-site treatment of high microcystin levels in water using polypropylene plastic.
J Environ Sci Health A Tox Hazard Subst Environ Eng
October 2018
Microcystin (MC) is a hepatotoxin produced by various cyanobacteria during harmful algal blooms (HAB's) in freshwater environments. Advanced treatment methods can remove MC from drinking water, but are costly and do not address recreational water exposure and ecosystem health concerns. Here we investigate the feasibility of utilizing plastics as a MC-adsorbing material, for use in water resources used for recreation, agriculture, aquaculture and drinking water.
View Article and Find Full Text PDFFreshwater harmful algal blooms (HABs), driven by nutrient inputs from anthropogenic sources, pose unique risks to human and ecological health worldwide. A major nutrient contributor is agricultural land use, specifically tile drainage discharge. Small lakes and ponds are at elevated risk for HAB appearance, as they are uniquely sensitive to nutrient input.
View Article and Find Full Text PDFHigh volume hydraulic fracturing operations: potential impacts on surface water and human health.
Int J Environ Health Res
August 2016
High volume, hydraulic fracturing (HVHF) processes, used to extract natural gas and oil from underground shale deposits, pose many potential hazards to the environment and human health. HVHF can negatively affect the environment by contaminating soil, water, and air matrices with potential pollutants. Due to the relatively novel nature of the process, hazards to surface waters and human health are not well known.
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