Publications by authors named "Igor K Shalik"
AAV- based vector improvements unrelated to capsid protein modification.
Front Med (Lausanne)
February 2023
Recombinant adeno-associated virus (rAAV) is the leading platform for delivering genetic constructs . To date, three AAV-based gene therapeutic agents have been approved by the FDA and are used in clinical practice. Despite the distinct advantages of gene therapy development, it is clear that AAV vectors need to be improved.
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- * While effective, viral vectors can trigger immune responses and disrupt cell metabolism, leading to potential side effects that need careful evaluation.
- * The review discusses how the entry of viral vectors and the delivery of non-coding RNAs can influence miRNA signaling pathways, which are crucial for gene expression regulation.