Publications by authors named "Igor I Turnaev"
YUCCA (YUCCA flavin-dependent monooxygenase) is one of the two enzymes of the main auxin biosynthesis pathway (tryptophan aminotransferase enzyme (TAA)/YUCCA) in land plants. The evolutionary origin of the YUCCA family is currently controversial: YUCCAs are assumed to have emerged via a horizontal gene transfer (HGT) from bacteria to the most recent common ancestor (MRCA) of land plants or to have inherited it from their ancestor, the charophyte algae. To refine YUCCA origin, we performed a phylogenetic analysis of the class B flavoprotein monooxygenases and comparative analysis of the sequences belonging to different families of this protein class.
View Article and Find Full Text PDFBackground: The passage through the cell cycle is controlled by complexes of cyclins, the regulatory units, with cyclin-dependent kinases, the catalytic units. It is also known that cyclins form several families, which differ considerably in primary structure from one eukaryotic organism to another. Despite these lines of evidence, the relationship between the evolution of cyclins and their function is an open issue.
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- Current methods for predicting transcription factor binding sites (TFBS) struggle with high false-positive rates because they mainly focus on core binding site sequence conservation.
- This study evaluated various Position Weight Matrix (PWM) algorithms to enhance the accuracy of TFBS predictions, especially for important biological processes related to growth, inflammation, obesity, and cell cycle regulation.
- The introduction of a new method called SiteGA, which considers structural interactions within the binding sites, demonstrated similar effectiveness to optimized PWMs, and the resulting recognition models can be accessed through a web tool for sequence analysis.