Publications by authors named "Igor Asanovic"
RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase complex (tRNA-LC) along with Ddx1, Cgi-99, Fam98B, and Ashwin. The human tRNA-LC or its individual subunits have been implicated in additional cellular processes including microRNA maturation, viral replication, DNA double-strand break repair, and mRNA transport.
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- The tRNA ligase complex (tRNA-LC) is involved in splicing precursor tRNAs and mRNA during the unfolded protein response (UPR) but is vulnerable to oxidative damage due to its catalytic subunit's structure.
- Research confirms that PYROXD1, an essential oxidoreductase, co-evolved with the tRNA-LC and helps maintain its activity by converting RTCB-bound NAD(P)H into an antioxidant form, thus protecting it from oxidative inactivation.
- Mutations in PYROXD1 that lead to human muscle diseases only partially preserve tRNA-LC function, highlighting the importance of this protective mechanism in cellular processes.