Publications by authors named "Igor A Sklyanik"
Saturated free fatty acids are thought to play a critical role in metabolic disorders associated with obesity, insulin resistance, type 2 diabetes (T2D), and their vascular complications via effects on the vascular endothelium. The most abundant saturated free fatty acid, palmitate, exerts lipotoxic effects on the vascular endothelium, eventually leading to cell death. Shear stress activates the endothelial AMP-activated protein kinase (AMPK), a cellular energy sensor, and protects endothelial cells from lipotoxicity, however their relationship is uncertain.
View Article and Find Full Text PDFBackground: Components of metabolic syndrome can be observed in patients with primary hyperparathyroidism (PHPT). The link between these disorders remains unclear due to the lack of relevant experimental models and the heterogeneity of examined groups. The effect of surgery on metabolic abnormalities is also controversial.
View Article and Find Full Text PDFArticle Synopsis
- Incretin hormones like GLP-1 help lower glucose levels, reduce appetite, and protect the heart, but their effects on fat tissue are not fully understood.
- Researchers investigated how liraglutide, a synthetic version of GLP-1, affects fat cell development and insulin sensitivity in 3T3-L1 adipocytes.
- The study found that liraglutide improves insulin sensitivity in mature fat cells through mechanisms involving adenylate cyclase, suggesting that it has a beneficial impact on fatty tissue.
Objective: To compare basal insulin and mTOR signaling in subcutaneous fat of obese T2DM vs. obese subjects with normal glucose tolerance (NGT), and correlate it with clinical parameters of carbohydrate metabolism and incretin secretion profiles.
Methods: Recruited were 22 patients with long (>10 years) and morbid (BMI > 35 kg/m) obesity, 12 of which had NGT and 10 had T2DM.