Criteria for Carotid Atherosclerotic Plaque Instability.

Background: The study aim is to determine the criteria for carotid atherosclerotic plaque instability with the use of an advanced ultrasound technology, immunohistochemical analysis, and electron paramagnetic resonance (EPR) and assess their correlations with histologic results.

Methods: A total of 92 patients were included in the study and were examined by ultrasound duplex scanning and ultrasound elastography. Plaques harvested during carotid endarterectomy were obtained for histologic analysis, immunofluorescent assay, and EPR spectroscopic measurements.

[Antithrombotic therapy after venous stenting].

Presented herein is a literature review considering the problems of using antithrombotic therapy after venous stenting. Described herein are the literature data according to which the authors give preference to anticoagulant therapy (low-molecular-weight heparins, vitamin K antagonists, direct oral anticoagulants). This is followed by considering the problems of duration of treatment depending on various clinical situations.

Diagnosis and surgical treatment of a persistent sciatic artery aneurysm.

The persistent sciatic artery is situated superficially in the gluteal region wherein it can be traumatized in normal daily activities: during a prolonged sitting position or while attempting to sit down. This leads to an early atherosclerotic lesion of the sciatic artery, to the development of aneurysmatic dilatation, and damage to the arterial wall. The present article describes a 72-year-old female patient presenting with a persistent sciatic artery of the left leg and a PSA aneurysm which consequently resulted in critical ischaemia of her left lower limb.

[Method of determining disease severity in women with pelvic varicose veins].

Background: Using assessment scales in clinical and research practice is one of fundamental reference methods of evaluation in human pathological states. Pelvic vein varicosity is an independent nosological entity within the framework of chronic vein diseases. Currently, the clinical methods of assessment in the aspect of a patient-oriented approach in this type of disease are largely understudied and still not duly defined.

Long-Term Results of Endovascular Treatment of Chronic Iliofemoral Venous Obstructive Lesions.

Objective: To evaluate the long-term results in endovascular treatment of iliofemoral venous obstructive lesions.

Methods: From January 2009 to March 2017, 75 patients were admitted for endovascular treatment of chronic obstructive lesions of the iliofemoral veins. Of these, 60 patients underwent stenting of postthrombotic obstructions and 15 patients stenting of nonthrombotic obstructive lesions of the iliac veins (May-Thurner syndrome in 11, for tumor-induced compression and cicatricial stenosis in 4).

Effect of Transition Metal Substitution on the Structure and Properties of a Clathrate-Like Compound Eu₇CuAs.

A series of substitutional solid solutions-Eu₇CuTAs (T = Fe, Co, Ni)-based on a recently discovered clathrate-like compound (Eu₇CuAs) were synthesized from the elements at 800 °C. Almost up to 50% of Cu can be substituted by Ni, resulting in a linear decrease of the cubic unit cell parameter from = 16.6707(1) Å for the ternary compound to = 16.

First Experience of Performing Hybrid Operations in Chronic Venous Obstructions of Iliofemoral Segments in Patients With Postthrombotic Syndrome.

Objective: To assess the first results of hybrid operations in chronic venous obstructions of iliofemoral segments in patients with postthrombotic syndrome (PTS).

Methods: Hybrid operations (open endovenectomy from the common femoral vein with arteriovenous fistula creation and iliac vein stenting) were performed in 12 patients diagnosed with PTS. All of the patients were diagnosed with severe chronic venous insufficiency.

Paramagnetic Manganese in the Atherosclerotic Plaque of Carotid Arteries.

The search for adequate markers of atherosclerotic plaque (AP) instability in the context of assessment of the ischemic stroke risk in patients with atherosclerosis of the carotid arteries as well as for solid physical and chemical factors that are connected with the AP stability is extremely important. We investigate the inner lining of the carotid artery specimens from the male patients with atherosclerosis (27 patients, 42-64 years old) obtained during carotid endarterectomy by using different analytical tools including ultrasound angiography, X-ray analysis, immunological, histochemical analyses, and high-field (3.4 T) pulse electron paramagnetic resonance (EPR) at 94 GHz.

Bacterial Communities Associated with Atherosclerotic Plaques from Russian Individuals with Atherosclerosis.

Atherosclerosis is considered a chronic disease of the arterial wall and is the major cause of severe disease and death among individuals all over the world. Some recent studies have established the presence of bacteria in atherosclerotic plaque samples and suggested their possible contribution to the development of cardiovascular disease. The main objective of this preliminary pilot study was to better understand the bacterial diversity and abundance in human atherosclerotic plaques derived from common carotid arteries of individuals with atherosclerosis (Russian nationwide group) and contribute towards the further identification of a main group of atherosclerotic plaque bacteria by 454 pyrosequencing their 16S ribosomal RNA (16S rRNA) genes.

Long-term results of the monocusp valve formation in the common femoral vein in patients with avalvular deep veins of the lower extremities.

Background: Aim of the study was to evaluate the long-term results of the monocusp valve formation in the common femoral vein (CFV) in patients with avalvular deep veins (ADV) of the lower extremities.

Methods: A total of 36 patients (24 women and 12 men) at the age varying from 37 to 58 years old were given surgical treatment during the period from 2008 to 2014. Six patients presented with congenital ADV, while the remaining 30 ADV had a consequence of the post-thrombotic lesion in the valves with the complete recanalization and manifested deep venous axial reflux.

[Stagewise treatment of a giant false paraanastomotic aneurysm of the abdominal aorta].

The article deals with a case report concerning successful stagewise treatment of a patient presenting with a giant false abdominal aortic paraanastomotic aneurysm having developed 2 months after an operation of linear prosthetic repair for a juxtarenal aneurysm with reimplantation of the left renal artery. The secondary operation was carried out 3 months after aortic reconstruction. The first stage consisted in performing endovascular prosthetic repair of the abdominal aortic paraanastomotic pseudoaneurysm by means of a bifurcated stent graft Endurant II (Medtronic), with the second stage being laparotomy with the removal of the retroperitoneal haematoma.

DFT study of the hydrolysis reaction in atranes and ocanes: the influence of transannular bonding.

Thermochemical kinetics of hydrolysis reactions of compounds with transannular intramolecular M…N bonds, i.e., atranes RM(OCH2CH2)3N and ocanes R2M(OCH2CH2)2NH (M = Si, Ge; R = F, Cl, Me), is studied at the B3LYP/aug-cc-pVDZ theoretical level.

Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma.

Epigenetic silencing of tumor suppressor genes (TSGs) by promoter methylation can be an early event in the multi-step process of carcinogenesis. Human chromosome 3 contains clusters of TSGs involved in many cancer types including nasopharyngeal carcinoma (NPC), the most common cancer in Southern China. Among ten candidate TSGs identified in chromosome 3 using NotI microarray, ITGA9 and WNT7A could be validated.

[Endovascular repair of an abdominal aortic aneurysm in a patient with horseshoe kidney].

Presented herein is a case report concerning successful endovascular treatment of a patient with an infrarenal abdominal aortic aneurysm combined with a horseshoe kidney. The diagnosis was verified by multispiral computed tomography. The patient underwent of endovascular repair of the abdominal aorta with a stent-graft AORFIX (Lombard Medical).

SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.

Epstein-Barr virus (EBV)-encoded Latent Membrane Protein 2A (LMP2A) is an EBV latency-associated protein regularly expressed in nasopharyngeal carcinoma (NPC). In B cells, LMP2A activity resembles that of a constitutively activated antigen receptor, which recruits the Syk tyrosine kinase to activate a set of downstream signaling pathways. LMP2A also downregulates cellular Syk levels.

Recycling of polymers: a review.

Plastics are inexpensive, easy to mold, and lightweight. These and many other advantages make them very promising candidates for commercial applications. In many areas, they have substantially suppressed traditional materials.

An assessment of DFT methods for predicting the thermochemistry of ion-molecule reactions of group 14 elements (Si, Ge, Sn).

Experimental mass-spectrometry data on thermochemistry of methide transfer reactions (CH₃)₃M(+) + M'(CH₃)₄ ↔ M(CH₃)₄ + (CH₃)₃M'(+) (M, M' = Si, Ge or Sn) and the formation energy of the [(CH₃)₃Si-CH₃-Si(CH₃)₃](+) complex are used as benchmarks for DFT methods (B3LYP, BMK, M06L, and ωB97XD). G2 and G3 theory methods are also used for the prediction of thermochemical data. BMK, M06L, and ωB97XD methods give the best fit to experimental data (close to chemical accuracy) as well as to G2 and G3 results, while B3LYP demonstrates poor performance.

Quantum chemical study of silanediols as metal binding groups for metalloprotease inhibitors.

DFT (B3LYP and M06L) as well as ab initio (MP2) methods with Dunning cc-pVnZ (n=2,3) basis sets are employed for the study of the binding ability of the new class of protease inhibitors, i.e., silanediols, in comparison to the well-known and well-studied class of inhibitors with hydroxamic functionality (HAM).

CYP2C9 and VKORC1 gene polymorphism is inessential for bleeding development under conditions of oral application of anticoagulant acenocoumarol in Russian patients at high risk of thromboembolic complications.

The study included 52 patients at a high risk of thromboembolic complications, with permanent atrial fibrillation. All patients were treated with acenocoumarol for 6 months and the incidence of hemorrhages was evaluated in all of them. All patients were genotyped by CYP2C9 and VKORC1.

Vibrational spectra of silatranes and germatranes XM(OCH₂CH₂)₃N (X=F,Cl,H; M=Si,Ge). The problem of the theoretical prediction of condensed phase spectra.

The structures of silatranes and germatranes XM(OCH(2)CH(2))(3)N (X=F,Cl,H; M=Si,Ge) were optimized and their vibrational spectra were calculated at the B3LYP/aug-cc-pVDZ level of theory. Theoretical frequencies of vibrations perpendicular to the C(3) axis (E type) are in good agreement with experimental values, while the axial vibrations (MX and M..

Effect of substituents and hydrogen bonding on barrier heights in dehydration reactions of carbon and silicon geminal diols.

Activation barrier heights for the dehydration reaction of geminal carbinols and silanediols R'R″X(OH)(2) (X = C, Si) were estimated at the B3LYP and MP2 levels of theory employing Dunning's correlation-consistent triple-zeta basis sets. It was shown that the barrier height for carbon derivatives steadily decreases upon substitution by R groups, usually termed as electron-donating, such as alkyl and amino groups. Substitution by electron-withdrawing groups leads, however, only to small changes in barrier heights compared to that of methanediol.

Theoretical study of the mechanisms of the hydrolysis and condensation reactions of silicon and titanium alkoxides: similarities and differences.

Stationary states for hydrolysis reactions in M(OCH(3))(4) + nH(2)O (M = Si, Ti; n = 1-3) systems are optimized at the B3LYP and MP2 levels with the Wachters basis set for titanium and the cc-pVDZ set for other atoms. Geometries of these states for M = Ti are characterized by trigonal bipyramidal (water molecules in front-side position) and octahedral coordination (for back-side position). Barrier heights for hydrolysis and condensation are substantially lower than those for silicon in keeping with experimental results.

Reductive splitting of cellulose in the ionic liquid 1-butyl-3-methylimidazolium chloride.

The depolymerization of cellulose is carried out in the ionic liquid 1-butyl-3-methylimidazolium chloride in the presence of hydrogen gas. First, the ketal 1,1-diethoxycyclohexane and cellobiose were used as model substrates. For the depolymerization of cellulose itself, the combination of a heterogeneous metal catalyst and a homogeneous ruthenium catalyst proved effective.

Rearrangements of [C(6)H(7)Si](+) cations. A radiochemical and quantum chemical study.

Nucleogenic cations were formed by beta-decay of phenylsilane tritiated at ortho- and para-positions of the benzene ring as well as at the silyl group and the products of their reactions with methyl tert-butyl ether were analyzed by radiochromatography. We found that the o-silatolyl cation was isomerized into the silabenzyl cation while the p-silatolyl cation was not. Furthermore, the silabenzyl cation was not converted into other isomers.

Role of structures with penta- and hexacoordinate silicon in the nucleophile-catalyzed hydrolysis of tetramethoxysilane.

The mechanism of the base catalyzed hydrolysis of tetramethoxysilane (TMOS), proposed earlier on the basis of experimental data, is assessed by theoretical methods, i.e. MP2 and B3LYP with 6-31G(d) and Dunning correlation-consistent basis sets.