Objective: Aim: To research subjective perceptions in additive color mixing.
Patients And Methods: Materials and Methods: 79 individuals were surveyed, and they determined the colors they perceived in two photographs. The results of color mixing were determined using statistical analysis, graphical modeling, and Python program figures.
plant family is comprised of resurrection species, namely and , that are native to the Southeast Asia and , , and , which are mainly found in the Balkan Peninsula. is known to be able to survive extreme and prolonged dehydration. Study was carried out after the dried plant Friv.
View Article and Find Full Text PDFObjective: To identify risk factors of postoperative ileus (POI) in elective colorectal cancer (CRC) surgery.
Material And Methods: A non-randomized retrospective study included 220 patients who underwent elective surgery for colorectal tumors. The indication for surgery was CRC stage 0-IV in 213 (96.
Aim: To evaluate the efficacy and safety of the proposed modified combined approach for laparoscopic splenic flexure mobilization (SFM).
Material And Methods: A multicenter non-randomized comparative study was conducted. The main group consisted of 12 patients who underwent laparoscopic modified combined SFM from December 2018 to May 2019, the control group consisted of 12 patients who underwent laparoscopic traditional combined SFM from 2013 to 2018.
Aim: To develop 'Cadaveric Course' of operative surgery for severe combined trauma for students, surgical residents, postgraduate students of medical universities and to compare its effectiveness with other approaches.
Material And Methods: 'Cadaveric course' program of operative surgery for severe combined trauma consisted of four stages. The first stage is theoretical course (2 weeks), the second stage - students' work in cadaveric operating theatre with instructors (5 weeks), the third stage - their independent work in 'cadaveric operating theatre (10 weeks), the fourth stage - analysis of the results and their comparison with those of 5 2-year residents (control group).
Aim: To develop system for students training in laparoscopic surgery by using of Wet-lab educational operating theatre.
Material And Methods: We have launched laparoscopic surgery teaching program for students of Ryazan State Medical University. This system includes several stages.
The preparative microbial synthesis of amino acids labelled with stable isotopes, including deuterium ( 2 H), suitable for biomedical applications by methylotrophic bacteria was studied using L-phenylalanine as example. This amino acid is secreted by Gram-negative aerobic facultative methylotrophic bacteria Brevibacterium methylicum, assimilating methanol via ribulose-5-monophosphate (RMP) cycle of assimilation of carbon, The data on adaptation of L-phenylalanine secreted by methylotrophic bacterium В. methylicum to the maximal concentration of deuterium in the growth medium with 98% 2 Н 2 O and 2% [ 2 Н]methanol, and biosynthesis of deuterium labelled L-phenylalanine With different levels of enrichment are presented.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
January 2014
The most common clinical type of multiple sclerosis (MS), affecting up to 85% of patients living with this disease, is relapsing remitting(RRMS). Relapses are associated with significant functional impairment and decreased quality of life. Residual symptoms after MS relapses may persist and lead to sustained disability.
View Article and Find Full Text PDFRGPU-207 compound and amiodarone in concentrations of 1, 10, 100 and 1000 microM produce dose-dependent and reversible effects on trans-membrane sodium, calcium, and potassium ion currents of neurons in pond snail and orb snail shellfish. In concentration of 1 microM, both compounds increased the amplitude of potassium ion currents, while not affecting the amplitude of sodium and calcium ion currents. In concentrations of 100 and 1000 microM, dose-dependent suppression of all currents (with predominant potassium ion current suppression) was observed.
View Article and Find Full Text PDFA 2H-labeled purine ribonucleoside inosine was microbiologically synthesized (yield, 3.9 g/L of culture liquid) using a deuterium-adapted strain ofthe gram-positive chemoheterotrophic bacterium Bacillus subtilis, cultivated in a heavy water medium with a high degree of deuteration (99.8 at % 2H) containing 2% hydrolysate of deuterated biomass of the methylotrophic bacterium Brevibacterium methylicum as a source of 2H-labeled growth substrate produced in an M9 minimal medium with 98% 2H20 and 2% [2H]-methanol.
View Article and Find Full Text PDFChanges in the membrane rest potential (RP), action potential (AP) and impulse activity (IA) in neurons of isolated central nervous system of Lymnaea stagnalis and Planorbarius corneus under the action of anxiolytic afobazole (2-mercaptobenzimidazole derivative) in 1, 10, 100 and 1000 microM concentrations have been studied using a microelectrode technique. It is established that afobazole produces a two-phase, dose-dependent and reversible effect on the electrical activity of neurons. Hyperpolarization by 5-8 mV in the first phase (1-100 microM) and depolarization by 8-10 mV in the second phase (1000 microM) have been observed.
View Article and Find Full Text PDFThe new glutamic acid derivative RGPU-135 (3-phenylglutamic acid hydrochloride, glutaron, neuroglutamin) produces dose-dependent and reversible modulation of transmembrane sodium, potassium and, to a greater extent, calcium ion currents in neurons of Lymnaea stagnalis and Planorbarius corneus mollusks at concentrations of 1, 10, 100, and 1000 microM. At concentrations within 1 - 10 microM micromole, Ca and K currents are activated rather insignificantly; at 100 pmole, the amplitude of calcium currents is increased by 5 - 10%; and at 1000 microM, the Na and K ion currents are suppressed by 5 - 12%. RGPU-135 does not influence the membrane surface charge potential and the gating of ion channels.
View Article and Find Full Text PDFEksp Klin Farmakol
August 2011
Neurophysiological experiments on anesthetized rats were used to study the effects of various doses (12.5, 25, 37.5 mg/kg, i.
View Article and Find Full Text PDFThe objective of this study was to describe a case of Alzheimer's disease in an ApoE epsilon2/epsilon2 homozygote. ApoE epsilon2/epsilon2 is the rarest of the apolipoprotein E genotypes, representing only 1.4% of the population.
View Article and Find Full Text PDFEksp Klin Farmakol
February 2009
The results of endocellular dialysis membrane potential monitoring show that cardiac glycosides digoxin and corglycon in concentration from 10(-12) to 10(-6) M influence the sodium, calcium and potassium ion currents in isolated snail (Lymnaea stagnalis) neurons in reversible and slightly dose-dependent manner. In low concentration (10(-12) - 10(-8) M) both substances increased all ionic currents by up to 5%, while in higher concentrations both drugs led to the suppression of ion currents. The most pronounced decrease (up to 26% relative to control) was observed for sodium ion current under the action of digoxin in a concentration of 10(-6) M.
View Article and Find Full Text PDFThere is extensive clinical evidence for the high efficacy of GABA-ergic drugs in prophylactic and abortive treatment of migraine and cluster headache, while the mechanisms of anticephalgic drugs action are not clear, in particular, because of insufficient number of investigations on experimental headache models. In this study, the influence of baclofen (i.v.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
September 2008
Efficacy and safety of the following antidepressants: amitryptiline (tricyclic antidepressant), escitalopram (selective inhibitor of serotonin reuptake), milnacipran (selective inhibitor of serotonin and noradrenalin reuptake) and maprotiline (selective inhibitor of noradrenalin reuptake) have been compared during the treatment of 120 patients with chronic daily headache. A positive effect was found for all drugs, in particular in the presence of depressive and anxiety symptoms. Most effective proved to be milnacipran and amitryptiline.
View Article and Find Full Text PDFExperiments on isolated neurons of Lymnaea stagnalis and Planorbis corneus using the intracellular dialysis and fixed membrane potential techniques showed that strophanthin G in a concentration range from 10(-11) to 10(-6) M produce dolse-dependent reversible suppression of the ion currents in potassium, calcium, and sodium channels. At the maximum concentration (10(-6) M), the maximum suppression (up to 55% of that in the control) was observed for the calcium ion current. At the minimum concentration (10(-12) M), the drug did not influence the sodium ion current, but slightly (approximately by 5%) increased the calcium and potassium ion currents.
View Article and Find Full Text PDFKhirurgiia (Sofiia)
February 2010
Unlabelled: The harmonic scalpel has been widely used in the field of thyroid surgery in recent years.
Aim: To present our initial results after the introduction of harmonic scalpel use during thyroid resections with minimally invasive open approach.
Patients And Methods: For the period from 01 January to 31 June 2008, 158 thyroid resections using harmonic scalpel have been done in our institution.
Changes of the transmembrane potassium, calcium, and sodium ion currents in isolated neurons of Lymnaea stagnalis snail under the action of ecdysteroid fraction (serpisten) from Serratula coronata L. applied from outside in 0.01 -1000 microg/ml concentrations have been studied using the voltage-clamp technique.
View Article and Find Full Text PDFEksp Klin Farmakol
December 2005
The effect of anxiolytic afobazole (2-[2-morpholino)ethylthio]-5-ethoxybenzimidazole dihydrochloride) at concentrations of 1, 10, 100 and 1000 microM on transmembrane calcium, sodium, and potassium (slow and rapid) ion currents in isolated neurons of Lymnaea stagnalis mollusks have been investigated. Afobazole was found to produce a dose-dependent reversible action: the drug increased all ion currents at concentrations below 100 microM and inhibited all ion currents at concentrations from 100 to 1000 microM. Afobazole at high concentrations accelerated the inactivation of slow potassium ion current and reversibly inhibited the fast potassium ion current.
View Article and Find Full Text PDFIntracellular dialysis and fixed membrane potential techniques were used to study the extracellular influence of antiarrhythmic drugs--brazidole (a new derivative of 2-mercaptobenzimidazole), amiodarone, sotalol, and hydroxyzine (a tranquilizer) in concentrations 1, 10, 100 and 1000 microM--on the slow potassium ionic transmembrane current in isolated neurons of Lymnnaea stagnalis mollusks. All drugs produced a doze-dependent and reversible suppression of the potassium ion current and accelerated the inactivation kinetics. With respect to the degree of current suppression at 100 microM concentration, the preparations under study can be arranged in the following order: brazidole = hydroxyzine > amiodarone > sotalol.
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