Publications by authors named "Ignasi Roca-Subira"
Biochim Biophys Acta
July 2016
Article Synopsis
- Recent studies on peptides have aimed at developing new bioactive compounds that help defend against pathogenic microorganisms, with a focus on the palindromic antimicrobial peptide Pa-MAP2 derived from Pleuronectes americanus.
- Comprehensive testing was conducted, including antibacterial activity against Gram-negative and positive bacteria, toxicity assessments on various human cell lines, and in vivo experiments with infected mice, revealing that Pa-MAP2 showed efficacy primarily against Gram-negative bacteria like E. coli.
- The peptide’s structure demonstrated a pH-dependent α-helix formation, with its activity linked to interactions with anionic lipids, indicating its potential as a therapeutic option for Gram-negative bacterial infections without causing cytotoxic effects.
