Publications by authors named "Ignacio Santos-Briones"
Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations.
Cristina Pardo-Camacho John-Peter Ganda Mall Cristina Martínez Marc Pigrau Elba Expósito Ignacio Santos-Briones
Cells
June 2022
Article Synopsis
- IBS (Irritable Bowel Syndrome) is a condition characterized by abdominal pain and varying bowel habits, particularly focusing on the diarrhea subtype (IBS-D), which shows changes in gut barrier and immune responses.
- A study analyzed jejunal biopsies and stool samples from both IBS-D patients and healthy controls, measuring factors like plasma cell activation, nerve proximity, and glycocalyx thickness, finding notable differences in humoral immune pathways.
- Results indicated that IBS-D patients had heightened plasma cell activity and lower glycocalyx thickness, linking these factors to gut dysfunction and clinical symptoms, suggesting the need for further research to clarify the mechanisms involved.