Publications by authors named "Ignacio Medina Castello"
General Purpose Graphic Processing Units (GPGPUs) constitute an inexpensive resource for computing-intensive applications that could exploit an intrinsic fine-grain parallelism. This paper presents the design and implementation in GPGPUs of an exact alignment tool for nucleotide sequences based on the Burrows-Wheeler Transform. We compare this algorithm with state-of-the-art implementations of the same algorithm over standard CPUs, and considering the same conditions in terms of I/O.
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- DISC1 is a strong candidate gene for schizophrenia, and evidence suggests its interaction partners also play a role in these disorders, prompting this study.
- Researchers used pooled sample 454 sequencing to analyze genetic variations in DISC1 and ten interaction partners among a population of Swedish individuals, finding a significantly higher mutation burden in schizophrenia patients compared to controls.
- The majority of rare missense variants were located in intrinsically disordered protein regions, indicating potential new mechanisms behind schizophrenia and underlining the importance of studying patient subgroups.