Publications by authors named "Ignacio Espanol-Morales"
Article Synopsis
- Pseudomonas aeruginosa bloodstream infections (BSI) in febrile neutropenic patients show a growing challenge due to increasing antibiotic resistance, complicating effective treatment based on international guidelines.
- A study involving 280 BSI cases revealed that 36% of isolated P. aeruginosa strains were resistant to recommended β-lactam antibiotics, with 21.1% classified as multidrug-resistant (MDR) and 11.4% as extensively drug-resistant (XDR).
- Inappropriate empirical antibiotic treatment (IEAT) was administered to 16.8% of patients, contributing to a 30-day mortality rate of 27.1%, highlighting an urgent need for new treatment strategies.
Objectives: To describe current resistance to the β-lactams empirically recommended in the guidelines in bloodstream infection (BSI) episodes caused by Gram-negative bacilli (GNB).
Methods: Retrospective, multicentre cohort study of the last 50 BSI episodes in haematological patients across 14 university hospitals in Spain. Rates of inappropriate empirical antibiotic therapy (IEAT) and impact on mortality were evaluated.
Prognostic value of procalcitonin and lipopolysaccharide binding protein in cancer patients with chemotherapy-associated febrile neutropenia presenting to an emergency department.
Biochem Med (Zagreb)
February 2019
Introduction: Cancer patients with chemotherapy-induced febrile neutropenia are a heterogeneous group with a significant risk of serious medical complications. In these patients, the Multinational Association for Supportive Care in Cancer (MASCC) score is the most widely used tool for risk-stratification. The aim of this prospective study was to analyse the value of procalcitonin (PCT) and lipopolysaccharide binding protein (LBP) to predict serious complications and bacteraemia in cancer patients with febrile neutropenia, compared with MASCC score.
View Article and Find Full Text PDFBackground Early diagnosis of infection is essential for the initial management of cancer patients with chemotherapy-associated febrile neutropenia (FN). In this study, we have evaluated two emerging infection biomarkers, pancreatic stone protein (PSP) and soluble receptor of interleukin 2, known as soluble cluster of differentiation 25 (sCD25), for the detection of an infectious cause in FN, in comparison with other commonly used infection biomarkers, such as procalcitonin (PCT). Methods A total of 105 cancer patients presenting to the emergency department were prospectively enrolled.
View Article and Find Full Text PDFValue of lipopolysaccharide binding protein as diagnostic marker of infection in adult cancer patients with febrile neutropenia: comparison with C-reactive protein, procalcitonin, and interleukin 6.
Support Care Cancer
July 2015
Purpose: Early detection of infection is essential for initial management of cancer patients with chemotherapy-associated febrile neutropenia in the emergency department. In this study, we evaluated lipopolysaccharide binding protein (LBP) as predictor for infection in febrile neutropenia and compared with other biomarkers previously studied: C-reactive protein (CRP), procalcitonin (PCT), and interleukin (IL)-6.
Methods: A total of 61 episodes of chemotherapy-associated febrile neutropenia in 58 adult cancer patients were included.