Publications by authors named "Ignacio Carvajal"
Article Synopsis
- - CMPA (cow's milk protein allergy) is a common food allergy in kids, and treatment involves avoiding cow's milk and using special formulas; the study investigates gut microbiota and dietary impacts after six months on a restrictive diet.
- - The research compared 21 CMPA patients with 24 healthy infants, analyzing their fecal microbiota and dietary patterns through various assessments.
- - Although growth rates were similar between CMPA infants on therapeutic formulas and those breastfed, the study highlighted differences in gut bacteria and nutrient intake, emphasizing the benefits of continued breastfeeding for CMPA infants.
Article Synopsis
- The study evaluates the long-term performance and safety of the extravascular implantable cardioverter-defibrillator (EV ICD) after initial findings showed its effectiveness for 6 months.
- A total of 316 patients were enrolled, with a successful implant in 299 cases, experiencing various arrhythmic events that were effectively treated using antitachycardia pacing (ATP) and shocks.
- The results indicated high success rates for both ATP (77.1%) and shock therapy (100%), with low rates of complications and inappropriate shocks over the three-year study period.
Summary: Genome assembly projects have grown exponentially due to breakthroughs in sequencing technologies and assembly algorithms. Evaluating the quality of genome assemblies is critical to ensure the reliability of downstream analysis and interpretation. To fulfil this task, we have developed the AssemblyQC pipeline that performs file-format validation, contaminant checking, contiguity measurement, gene- and repeat-space completeness quantification, telomere inspection, taxonomic assignment, synteny alignment, scaffold examination through Hi-C contact-map visualization, and assessments of completeness, consensus quality and phasing through k-mer analysis.
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- Researchers examined the genetic factors influencing the diverse composition of floral nectar, particularly focusing on Mānuka (Leptospermum scoparium) and its high levels of dihydroxyacetone (DHA), which leads to the production of the antimicrobial compound methylglyoxal in honey.
- Through RNA sequencing and QTL mapping, they identified key genes, particularly a phosphatase gene named LsSgpp2, that are linked to the accumulation of DHA in nectar.
- The study indicates that the DHA content in Mānuka nectar is polygenically controlled, meaning multiple genes influence this trait, highlighting the importance of plant genetics in nectar composition variability.
The objective was to evaluate the need for vitamin D prophylaxis in healthy infants. This was a prospective and randomized study performed at primary care clinics. Eighty-eight full-term 1-month-old healthy infants were randomly assigned to receive (n = 41) or not (n = 47) 402 IU/d of vitamin D for 1 year.
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