Publications by authors named "Ifeanyichukwu C Ogobuiro"
Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which inhibit T-cell function through JAK2/STAT3-regulated arginase activity. To overcome limitations of systemic inhibition of PMN-MDSCs in cancer-bearing patients-i.e.
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- KRAS-TP53 genomic coalteration in pancreatic ductal adenocarcinoma (PDAC) leads to immune exclusion and poor survival, driven by the key mediator Cxcl1 and its interaction with neutrophils.
- Silencing Cxcl1 in specific PDAC models reprograms neutrophils, enhancing T-cell activity and controlling tumor growth through T-cell dependence.
- The study reveals that neutrophil-derived TNF plays a crucial role in maintaining immunosuppression and inflammation in PDAC, suggesting that targeting TNF signaling could improve chemotherapy effectiveness.