Publications by authors named "Ifeanyi Okoye"

Background: Timely and reliable data are crucial for clinical, epidemiologic, and program management decision making. Electronic health information systems provide platforms for managing large longitudinal patient records. Nigeria implemented the National Data Repository (NDR) to create a central data warehouse of all people living with human immunodeficiency virus (PLHIV) while providing useful functionalities to aid decision making at different levels of program implementation.

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The COVID-19 pandemic has caused significant morbidity and mortality since its emergence in December 2019. In Nigeria, the government inaugurated the Presidential Task Force on COVID-19 to coordinate resources while the Nigeria Centre for Disease Control led the public health response. The Nigeria Ministry of Defence Health Implementation Programme (MODHIP), in partnership with the US Army Medical Research Directorate - Africa/Nigeria, responded immediately to the pandemic by establishing a public health emergency operations center to coordinate the military response in support of national efforts.

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Article Synopsis
  • The study assessed the effectiveness of first-line antiretroviral therapy among 325 HIV patients in four Nigerian military hospitals, aiming to measure virological suppression.
  • Results showed that 86.3% of participants had HIV viral RNA below the critical threshold of 1000 copies/ml, indicating successful treatment.
  • However, among those not achieving suppression, a significant proportion exhibited drug resistance mutations, highlighting the importance of monitoring for treatment failure as recommended by WHO guidelines.
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HIV-1 viral load (VL) monitoring is recommended but seldom performed in resource-constrained countries. An evaluation of patients receiving first-line antiretroviral therapy in a multicountry PEPFAR program (RV288) was performed to determine the rates and predictors of virologic suppression. Resistance data from treatment failures are available from Uganda and Nigeria.

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