Impact of extracorporeal blood pump gap sizes on the performance and hemocompatibility under off-design operation.

Background: Hemocompatibility remains the dominant challenge in rotary blood pumps, and more information on the relationship between individual pump design features, hemodynamics, and blood trauma in various operation conditions is necessary. The study evaluated the variation of gap sizes in extracorporeal blood pumps concerning their influence on blood compatibility, particularly during off-design conditions.

Methods: We developed a parametric generic blood pump framework for in-silico and in-vitro design feature analysis.