Publications by authors named "Ieva Vanaga"
Introduction: Pathogenic mechanisms and long-term consequences of COVID-19 require attention in studies on SARS-CoV-2. The association of the severity of COVID-19 with genetic factors, such as human leukocyte antigen (HLA) genes, remains underexplored. Our study assessed the relationships between HLA class II alleles and COVID-19 severity and blood-based indicators of systemic inflammation and organ damage, serum markers of epithelial cell apoptosis such as caspase-cleaved CK18 fragment M30 (CK18-M30) and the extracellular matrix product hyaluronic acid (HA).
View Article and Find Full Text PDFBackground: Studies on a new coronavirus disease (COVID-19) show the elevation of liver enzymes and liver fibrosis index (FIB-4) independently on pre-existing liver diseases. It points to increased liver fibrogenesis during acute COVID-19 with possible long-term consequences. This study aimed to assess liver fibrosis in COVID-19 patients by serum hyaluronic acid (HA) and FIB-4.
View Article and Find Full Text PDFArticle Synopsis
- This study investigated liver injury patterns in patients who had experienced COVID-19, using a technique called multiparametric ultrasound (mpUS).
- Ninety participants were assessed, including 56 who had SARS-CoV-2 infections and 34 healthy controls, with findings showing significant liver abnormalities in those who had COVID-19.
- Results indicated that worse liver health was linked to more severe COVID-19 symptoms and higher body mass index, suggesting mpUS may be better than CT or MRI for detecting liver damage post-infection.