[Different therapeutic approaches for chronic diffuse liver lesions using ornicetil, lactulose, etimizol and corinfar].

Different therapeutic regimens were tried in 67 patients with hepatic cirrhosis and in 54 patients with chronic hepatitis depending on the leading pathological syndrome. Treatment schemes involved the use of the drug ornicetil in patients having acute episodes of portal systemic encephalopacy, lactulose in those presenting with an increased content of ammonia in the blood and symptoms of chronic portal systemic encephalopacy; etimizol was given to those patients with an apperant antioxidant imbalance. Differentiated approaches to the institution of curative measures permitted improving considerably the patients' medical rehabilitation, achieving regression of pathological manifestations.

[Use of pentoxifylline in the treatment of systemic scleroderma].

Analyzes in the paper are chief pharmacological effects of pentoxifylline; the necessity is substantiated of its prescription in a combined therapy of systemic scleroderma (SSD). As many as 220 SSD patients on an in-patient care were examined. Apart from general clinical, biochemical, immunological methods of investigation, the condition of the microcirculation system was studied, the level of the tumor necrosis serumal factor alfa (TNF-alpha) was measured.

[Role of interleukin-1 and interleukin-2 in the pathogenesis of systemic scleroderma].

The purpose of a research was to define the levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) in patients with systemic scleroderma (SSc) and to analyse their dependence on the course of the illness. 75 patients with SSc and 20 apparently healthy people were examined. Besides the well-known clinical-biochemical and instrumental investigations, the levels of IL-1 and Il-2 in all the patients were determined in serum with an immunoenzymatic method using a set of reactants Pro Con IL-1b and Pro Con IL-2 (Russia).

[Osteocalcin--a marker of bone metabolism in rheumatoid arthritis patients].

Blood serum concentration of osteocalcin was studied in 53 patients with rheumatoid arthritis. Osteocalcin (noncollagenous protein of bony tissue) is a marker of bony tissue formation known to be of high informative value. There were no significant differences in values for osteocalcin concentration between patients with rheumatoid arthritis and healthy people.

[The complex assessment of the consequences of anthropogenic environmental pollution and the principles for their prevention].

Genetic monitoring on the basis of clinical-epidemiologic indices of congenital and hereditary pathology among newborns and spontaneous abortions as well as morphogenetic finding analysis in different age group representatives have been carried out. Mutation process dynamics in various ecological zone populations has been established. Dermatoglyphics and karyograme changes have been revealed their expressiveness depended on the general state of the organism, age and hereditary predisposition to polygenic diseases.

[The morbidity indices of subjects with incorporated radioactive iodine].

With the purpose of detecting long-term somatic effects of incorporated iodine, an analysis was performed of health disorders in those subjects (n = 1040) who received 131 I in therapeutic dosages 25 to 30 years ago. Discordances in pituitary-thyroid- and pituitary-adrenal axes were found to result in excessive metabolic-degenerative and vegetovascular type morbidity rates compared with the general population. Mortality index exceeds that of in the population 2.

[The dynamics of the glycocholic acid content of the bile in patients with chronic inactive hepatitis].

The studies made showed the content of bile acids in the bile, in particular that of glycocholic one, to get moderately reduced in chronic inactive hepatitis, which fact is thought to bring about dyspeptic events showing up in the above conditions: changeable stools, periodic moderate abdominal distention, nausea and other manifestations. It has been shown that the hepatic cells functional capacity may be medically controlled. Combined use in a therapeutic complex of riboxin and ricavit resulted in normalization of the glycocholic acid content in the patients' bile.

[Enteroinsular hormones in chronic gastritis with secretory insufficiency].

The blood serum content of secretin, vasointestinal peptide (VIP), glucagon and insulin was studied in 112 patients with chronic gastritis presenting with secretory deficiency, and 12 essentially healthy subjects. It was established that in surface, fundal and pangastritis the levels of secretin and VIP did not differ from the values in healthy individuals. The secretin concentration tended to be the lowest in atrophic fundal and atrophic pangastritis.

[The effect of etimizol on the glycosaminoglycan level in patients with osteoarthrosis deformans].

Aetymizolum was studied for its efficacy in the treatment of patients with osteoarthrosis. The results obtained suggest that aethymizolum is capable of correcting the levels of glycosaminoglucans in the patients' blood serum. With the content of the latter being dependent upon the degree of the articular cartilage destruction in osteoarthrosis deformans, it is suggested that aethymizolum while being endowed with reparative and membrane stabilizing properties may at the same time influence the articular cartilage metabolism and decrease the intensity of the destruction of the later.

[The clofelin and nifedipine treatment of hypertensive crises in elderly patients].

Simultaneous use of clophelin and nifedipine for hypertensive attacks in elderly subjects resulted in a sharp fall of the AP due to decrease of the cardiac ejection. In consecutive use of these drugs nifedipine was followed 2 hours later by clophelin in small dosterinemia and increase of cardiac ejection were observed. The consecutive method is ses and a prolonged reduction of AP, peripheral resistance, diastolic values, hyperaldo- preferred in the elderly patients.

[The level of total immunoglobulin E in the blood serum of rheumatism patients].

The mean level of total IgE in the sera of patients with active rheumatism was significantly higher than during non-active phase of the disease and in healthy blood donors. The highest level of hyper-IgE-emia is observed in the continuously relapsing variant of rheumatism. Increased content of total serum IgE in active rheumatism is observed both in manifest and in latent variants of the disease.