[An experimental study of the mechanism of the combined action on the body of ionizing radiation, pesticides, nitrates and lead and cadmium salts].

The studies made showed that repeated combined action of chemical factors (pesticides of different chemical groups, Cd and Pb salts, nitrates) in the doses studied resulted in an increase of the lipid peroxidation (LPO) in tissues, accumulation of its end products in biosubstrates, and activation of catalase and peroxidase oxidoreductases in blood of test animals. Combined action of chemical factors and gamma radiation was found out to make for increasing in lipid peroxidation and involving of ceruloplasmin in the LPO inhibition. Depletion of the antioxidant system in repeated irradiations against the background of chemical loading was accompanied by accumulation of the LPO products.

[The transplacental uptake of xenobiotics].

It was shown theoretically and experimentally that the placenta does not prevent entering of toxic chemical compounds to the fetal blood but vice versa provides their larger concentration than in the blood of the mother. Namely this may be related to an increase of the incidence of congenital abnormalities and other kinds of pathology in the newborn.