Publications by authors named "Idriss Lahlou Amine"
The goal of our study was to explore the association of the polymorphisms in the JAK/STAT pathway among Moroccan COVID-19 patients, using a case-control approach. Next-generation sequencing was employed to investigate the IFNAR1, IFNAR2, JAK1, TYK2, STAT2, and IRF9 genes within the JAK/STAT pathway. We also performed an in silico study to examine the rare variants in this pathway.
View Article and Find Full Text PDFBackground: The SARS-CoV-2 is an extremely contagious and acute viral disease mainly affecting humans.
Objective: To estimate seroprevalence of SARS-CoV-2 neutralizing antibodies (NAbs) for illegible armed force individuals living in Rabat, Morocco.
Method: A convenience sample (N = 2662) was conducted from May 2020 to February 2021.
Introduction: This study was conducted to assess the difference in biosafety behaviors among nurses working in a levels 2 and 3 hospital unit in Morocco and the need for additional biosafety training before working in a high-containment facility.
Methods: A prospective cross-sectional and observational study was conducted among new and experienced nurses in the Center of Virology and Tropical Infectious Diseases of the Military Teaching Hospital Mohammed V of Rabat, Morocco, between December 1, 2017 and February 28, 2018 (3 months). We compared behaviors in biosafety practices (donning gloves, handwashing, etc) between the 2 groups, and data were collected by observing workers directly or via camera.
Introduction: This study was conducted to assess the biosafety knowledge among laboratory staff working in Morocco.
Methods: A cross-sectional study was conducted among all laboratory staff in public and private clinical diagnostic and research laboratories between December 5, 2018, and January 5, 2018. Data were collected using a self-administered questionnaire distributed via Google Form.
Monitoring the use of antibacterial agents in food-producing animals is crucial in order to reduce antimicrobial resistance, selection and dissemination of resistant bacterial strains, and drug residues in the animal food products. The broiler production sector is considered a great consumer of antibacterials and incriminated in the rise of antimicrobial resistance level in zoonotic bacterial pathogens such as Escherichia coli, Salmonella and Campylobacter. Following recommendations from the OIE and WHO, a survey was conducted about the use and consumption of several antibacterial agents in Moroccan broiler flocks.
View Article and Find Full Text PDFBackground: The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection.
Methods: A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) 'pandemic influenza'.
Article Synopsis
- BRCA1 mutations are a significant factor in hereditary and sporadic breast and ovarian cancer, but their impact in MENA populations has been under-researched.
- A systematic review revealed 31 mutations across 547 patients, with a notable founder mutation identified in North African families.
- This knowledge is crucial for enhancing screening programs and clinical management of these cancers in the region, highlighting the need for targeted preventive strategies for mutation carriers.
Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.
Lancet Respir Med
May 2014
Article Synopsis
- The study analyzed the effectiveness of neuraminidase inhibitors in reducing mortality among hospitalized patients with the H1N1 virus during the pandemic.
- Data from 29,234 patients across 78 studies was examined to assess the impact of these antiviral treatments.
- Results showed that neuraminidase inhibitors reduced mortality risk, particularly when administered early (within two days of symptom onset), highlighting the importance of prompt treatment.
Introduction: The objective of this study was to determine the prevalence of West Nile Virus infection in the southern provinces of Morocco.
Methodology: A total of 250 sera, collected during 2012 in the province of Dakhla, were analyzed by microneutralisation assay.
Results: WNV-neutralizing antibodies were detected in 13 samples (5.
To study genetic evolution of Moroccan influenza A(H1N1)pdm09 virus strains, we conducted a molecular characterization of the hemagglutinin gene subunit 1 (HA1) of 36 influenza A(H1N1)pdm09 virus strains. The stains were collected from patients in Rabat and Casablanca during two influenza seasons 2009-2010 and 2010-2011. Nucleotide and amino acid sequences of 14 influenza A(H1N1)pdm09 virus strains from 2009 to 2010 were ~97 and 99 %, respectively, similar to the reference strain A/California/07/2009 (H1N1).
View Article and Find Full Text PDFArticle Synopsis
- There is a lack of comprehensive studies on BRCA mutations in the Moroccan population, prompting an analysis of the BRCA1 gene in 121 Moroccan women with breast cancer.
- The study found 31.6% of familial cases and 1% of early-onset sporadic cases had BRCA1 mutations, uncovering several specific pathogenic mutations and pointing to the c.798_799delTT mutation as a significant non-Jewish founder mutation in Northern Africa.
- The research highlights the genetic diversity in the Moroccan population, with implications for genetic counseling and clinical management, while also indicating that BRCA2's role in breast cancer is being investigated.
Coxsackievirus A24 variant is, together with enterovirus 70 and adenoviruses, the major etiological agent involved in acute hemorrhagic conjunctivitis outbreaks worldwide. However, the standard virus isolation method followed by serotyping or VP1 region sequencing is time-consuming. A rapid method for the detection of coxsackievirus A24 variant from conjunctival swab specimens would be useful in the context of explosive and extensive outbreaks.
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