Association of response to combined interferon alpha-2b and ribavirin therapy in patients of chronic hepatitis c with serum alanine aminotransferase levels and severity of the disease on liver biopsy.

Background: Raised serum alanine aminotransferase (serum ALT) levels indicate active liver disease while liver biopsy has been considered the 'gold standard' for assessing the severity of disease in patients of chronic Hepatitis C. The response of these patients to standard treatment regimen of interferon (INF)-alpha-2b and ribavirin for 24 weeks have been studied.

Objective: The objective of this study was to evaluate the association of response to combined INF alpha-2b and ribavirin therapy in patients of chronic hepatitis C with serum ALT levels and severity of the disease on liver biopsy.

The Journal of Ayub Medical College: a 10-year bibliometric study.

Objective: To conduct a bibliometric evaluation of the Journal of Ayub Medical College (JAMC), Abbottabad, Pakistan.

Methods: The data of articles, citations and authors of JAMC from 1997 to 2006 were collected and analysed in terms of bibliometric parameters.

Results: The number of articles published per year ranges between 27 and 97; most of the articles (47.

Rating Pakistani medical journals using the principles of citation analysis.

Objective: To quantify the impact of Pakistani Medical Journals using the principles of citation analysis.

Methods: References of articles published in 2006 in three selected Pakistani medical journals were collected and examined. The number of citations for each Pakistani medical journal was totalled.

Synergistic interaction of epinephrine and calcium ionophore in platelet aggregation.

Background: Platelets play a key role in haemostasis. Human Platelets contain alpha2 adrenergic receptors, which are coupled with guanine nucleotide proteins (G proteins). The platelet activation involves a number of receptors for agonists.

Synergistic interaction of adenosine diphosphate-epinephrine and epinephrine-collagen in aggregation of human platelets.

Background: Efficient hemostasis in human body depends on a complicated series of events which actively involve blood platelets. Platelets exhibit diverse responses in a variety of agonists. In vivo, most of the agonists act in synergism, causing aggregation of platelets.