Dementia Care Research and Psychosocial Factors.

Background: The progression of diabetes mellitus (DM) has been associated with changes in brain structure and function, often referred to as "diabetic encephalopathy," which is characterized by cognitive and neurochemical dysfunction, and identifiable structural changes in brain imaging. This study investigated the effect of Moringa leaf-supplemented diets (MLSD) on cognition, acetylcholinesterase (AChE), adenosine deaminase (ADA) and arginase activities, reactive oxygen species (ROS), total-thiol (T-SH), inflammatory cytokines (TNF-α, NF-κB, IL-6, and IL-10) levels, caspase-3 expression, and nuclear factor erythroid 2-related factor-2 (Nrf2) levels in the brain of DM rats treated with 25 mg/kg bwt acarbose (ACA).

Method: The normal control (NC) rats and diabetic rats were grouped as follows: NC rats, untreated DM rats, DM rats plus ACA, DM rats plus ACA and 2% MLSD, and DM rats plus ACA and 4% MLSD.

Characterization and neuroprotective properties of alkaloid extract of Delile in experimental models of Alzheimer's disease.

This study emphasized on the neuroprotective properties of bitter leaf alkaloid-rich extract (BLAE) using transgenic fruit fly ( []) model and scopolamine-induced amnesia rats. antioxidant properties and modulatory effects on key neuronal enzymes were carried out. Thereafter, fruit flies expressing human amyloid precursor protein () and genes were treated with BLAE for 7 d to determine survival rate, BACE-1, acetylthiocholine (AChE), glutathione-S-transferase (GST), and catalase activities.