NANO.PTML model for read-across prediction of nanosystems in neurosciences. computational model and experimental case of study.

Neurodegenerative diseases involve progressive neuronal death. Traditional treatments often struggle due to solubility, bioavailability, and crossing the Blood-Brain Barrier (BBB). Nanoparticles (NPs) in biomedical field are garnering growing attention as neurodegenerative disease drugs (NDDs) carrier to the central nervous system.

Efficient Magneto-Luminescent Nanosystems based on Rhodamine-Loaded Magnetite Nanoparticles with Optimized Heating Power and Ideal Thermosensitive Fluorescence.

Nanosystems that simultaneously contain fluorescent and magnetic modules can offer decisive advantages in the development of new biomedical approaches. A biomaterial that enables multimodal imaging and contains highly efficient nanoheaters together with an intrinsic temperature sensor would become an archetypical theranostic agent. In this work, we have designed a magneto-luminescent system based on FeO NPs with large heating power and thermosensitive rhodamine (Rh) fluorophores that exhibits the ability to self-monitor the hyperthermia degree.

Towards the design of contrast-enhanced agents: systematic Ga doping on magnetite nanoparticles.

The main objective of the preparation of the FeGaO (0.14 ≤ ≤ 1.35) system was to further the knowledge of the magnetic response of Ga-doped magnetite for application as MRI contrast agents.

A Milestone in the Chemical Synthesis of FeO Nanoparticles: Unreported Bulklike Properties Lead to a Remarkable Magnetic Hyperthermia.

Among iron oxide phases, magnetite (FeO) is often the preferred one for nanotechnological and biomedical applications because of its high saturation magnetization and low toxicity. Although there are several synthetic routes that attempt to reach magnetite nanoparticles (NPs), they are usually referred as "IONPs" (iron oxide NPs) due to the great difficulty in obtaining the monophasic and stoichiometric FeO phase. Added to this problem is the common increase of size/shape polydispersity when larger NPs ( > 20 nm) are synthesized.

Shaping Up Zn-Doped Magnetite Nanoparticles from Mono- and Bimetallic Oleates: The Impact of Zn Content, Fe Vacancies, and Morphology on Magnetic Hyperthermia Performance.

The currently existing magnetic hyperthermia treatments usually need to employ very large doses of magnetic nanoparticles (MNPs) and/or excessively high excitation conditions ( × > 10 A/m s) to reach the therapeutic temperature range that triggers cancer cell death. To make this anticancer therapy truly minimally invasive, it is crucial the development of improved chemical routes that give rise to monodisperse MNPs with high saturation magnetization and negligible dipolar interactions. Herein, we present an innovative chemical route to synthesize Zn-doped magnetite NPs based on the thermolysis of two kinds of organometallic precursors: (i) a mixture of two monometallic oleates (FeOl + ZnOl), and (ii) a bimetallic iron-zinc oleate (Fe Zn Ol).

Exploring the potential of the dynamic hysteresis loops via high field, high frequency and temperature adjustable AC magnetometer for magnetic hyperthermia characterization.

Aim: The Specific Absorption Rate (SAR) is the key parameter to optimize the effectiveness of magnetic nanoparticles in magnetic hyperthermia. AC magnetometry arises as a powerful technique to quantify the SAR by computing the hysteresis loops' area. However, currently available devices produce quite limited magnetic field intensities, below 45mT, which are often insufficient to obtain major hysteresis loops and so a more complete and understandable magneticcharacterization.

Highly Reproducible Hyperthermia Response in Water, Agar, and Cellular Environment by Discretely PEGylated Magnetite Nanoparticles.

Local heat generation from magnetic nanoparticles (MNPs) exposed to alternating magnetic fields can revolutionize cancer treatment. However, the application of MNPs as anticancer agents is limited by serious drawbacks. Foremost among these are the fast uptake and biodegradation of MNPs by cells and the unpredictable magnetic behavior of the MNPs when they accumulate within or around cells and tissues.

Outstanding heat loss via nano-octahedra above 20 nm in size: from wustite-rich nanoparticles to magnetite single-crystals.

Most studies on magnetic nanoparticle-based hyperthermia utilize iron oxide nanoparticles smaller than 20 nm, which are intended to have superparamagnetic behavior (SP-MNPs). However, the heating power of larger magnetic nanoparticles with non-fluctuating or fixed magnetic dipoles (F-MNPs) can be significantly greater than that of SP-MNPs if high enough fields (H > 15 mT) are used. But the synthesis of larger single nanocrystals of magnetite (FeO) with a regular shape and narrow size distribution devoid of secondary phases remains a challenge.

Mn-Doping level dependence on the magnetic response of MnFeO ferrite nanoparticles.

Manganese/iron ferrite nanoparticles with different Mn doping grades have been prepared by a thermal decomposition optimized approach so as to ascertain the doping effect on magnetic properties and, especially, on the magnetic hyperthermia response. The oxidation state and interstitial position of Mn in the spinel structure is found to be critical. The particle size effect has also been studied by growing one of the prepared samples (from 10 to 15 nm in diameter) by a seed mediated growth mechanism.

Multilayered inorganic-organic microdisks as ideal carriers for high magnetothermal actuation: assembling ferrimagnetic nanoparticles devoid of dipolar interactions.

The two major limitations for nanoparticle based magnetic hyperthermia in theranostics are the delivery of a sufficient number of magnetic nanoparticles (MNPs) with high heating power to specific target cells and the residence time of the MNPs at the target location. Ferromagnetic or Ferrimagnetic single domain nanoparticles (F-MNPs), with a permanent magnetic dipole, produce larger magnetic and thermal responses than superparamagnetic nanoparticles (SP-MNPs) but also agglomerate more. MNP agglomeration degrades their heating potential due to dipolar interaction effects and interferes with specific targeting.

Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice.

Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fields to heat superparamagnetic nanoparticles on the neuronal membrane.

Model Driven Optimization of Magnetic Anisotropy of Exchange-coupled Core-Shell Ferrite Nanoparticles for Maximal Hysteretic Loss.

This study provides a guide to maximizing hysteretic loss by matching the design and synthesis of superparamagnetic nanoparticles to the desired hyperthermia application. The maximal heat release from magnetic nanoparticles to the environment depends on intrinsic properties of magnetic nanoparticles (e.g.

Fe3O4 nanoparticles prepared by the seeded-growth route for hyperthermia: electron magnetic resonance as a key tool to evaluate size distribution in magnetic nanoparticles.

Monodispersed Fe3O4 nanoparticles have been synthesized by a thermal decomposition method based on the seeded-growth technique, achieving size tunable nanoparticles with high crystallinity and high saturation magnetization. EMR spectroscopy becomes a very efficient complementary tool to determine the fine details of size distributions of MNPs and even to estimate directly the size in a system composed of a given type of magnetic nanoparticles. The size and size dispersity affect directly the efficiency of MNPs for hyperthermia and EMR provides a direct evaluation of these characteristics almost exactly in the same preparation and with the same concentration as used in hyperthermia experiments.