Publications by authors named "Ido Weiser-Bitoun"
The standard polygraph, or lie detector, is limited by its reliance on average heart rate, subjective examiner interpretation, and the need for direct subject contact. Remote photoplethysmography (rPPG) offers a promising contactless alternative, by using facial videos to extract heart rate variability (HRV). We introduce "LieRHRV," a remote lie detection algorithm based solely on extracted HRV parameters.
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- - The study looked into how the autonomic nervous system (ANS) and intrinsic mechanisms of sinoatrial node (SAN) cells influence heartbeat patterns and variability, especially as people age.
- - It involved recording ECG data from young adults (under 21) and older adults (41-78) while examining their heart rate behaviors in normal states and after blocking ANS activity with specific medications.
- - The results revealed that young adults' heartbeat variability was mainly influenced by intrinsic mechanisms, whereas for older adults, both ANS and intrinsic factors played roles, highlighting the impact of anesthesia on heart regulation in different age groups.
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- Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can be important for drug testing and understanding heart diseases, but their normal physiological functions need more investigation.
- The study focuses on the automaticity of hiPSC-CMs, which is influenced by two types of "clocks" (Ca2+ and membrane clocks) and explores how they interact through local Ca2+ releases (LCRs).
- Findings show that changes in the signaling pathways that regulate these clocks can significantly affect the beating rate and automaticity of hiPSC-CMs, indicating their potential similarity to natural pacemaker cells in the heart.
Article Synopsis
- Protein kinase A (PKA) plays a crucial role in various cellular processes by regulating cAMP signaling in different cell compartments, including the cytosol and mitochondria.
- The study utilized FRET-based sensors to explore PKA signaling and its interaction with calcium (Ca) in rabbit atrial cells during electrical stimulation, revealing a decrease in PKA activity when treated with H-89.
- It was found that PKA activity varies across compartments, showing diminished activity in the outer mitochondrial membrane (OMM) compared to the cytosol and mitochondrial matrix (MM), indicating a complex regulation of PKA signaling linked to Ca dynamics and cellular excitability.
Background: The interactions between the autonomic nervous system (ANS), intrinsic systems (e.g., endocrine), and internal pacemaker mechanisms govern short (milliseconds-seconds)- and long (seconds-minutes)-range heart rate variability (HRV).
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- Heart rate and heart rate variability (HRV) are influenced by the autonomic nervous system (ANS) and the sinoatrial node (SAN), but their individual contributions to HRV remain unclear, complicating treatment for heart issues.
- A study analyzed HRV in dogs and humans, revealing that the SAN primarily affects long-term HRV while the ANS impacts short-term HRV; similar trends were observed in human patients with heart conditions.
- The findings suggest that both SAN and ANS deterioration is linked to heart disease and aging, and that SAN characteristics can be non-invasively assessed from heart beat intervals, potentially improving diagnostic methods.
The time variation between consecutive heartbeats is commonly referred to as heart rate variability (HRV). Loss of complexity in HRV has been documented in several cardiovascular diseases and has been associated with an increase in morbidity and mortality. However, the mechanisms that control HRV are not well understood.
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