Publications by authors named "Idil Esen"
Article Synopsis
- The study explores the role of specific immune pathways (IL-12-IFNγ-Th1 and IL-6-IL-23-Th17) in Giant Cell Arteritis (GCA) and how phosphorylated STAT proteins (pSTAT) in immune cells could help tailor treatments for patients.
- Researchers analyzed immune cells from GCA patients, infection controls, and healthy individuals, noting a decrease in pSTAT3+CD4+T-cells in GCA patients, especially those with high serum IL-6 levels.
- The findings suggest that measuring pSTAT3 levels can predict the duration of glucocorticoid treatment needed for GCA patients, helping to personalize their treatment plans in the future.
Introduction: Giant cell arteritis (GCA) is a vasculitis of the medium- and large-sized arteries. Interferon type I (IFN-I) is increasingly recognized as a key player in autoimmune diseases and might be involved in GCA pathogenesis, however evidence is limited. IFN-I activates Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways, leading to increased expression of interferon stimulated genes.
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- Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory diseases affecting older adults, requiring long-term glucocorticoid treatment that can lead to additional health issues.
- A study compared metabolic profiles and comorbidities of treatment-naïve patients with GCA and PMR to a general population, finding higher glycated hemoglobin and lower cholesterol levels in GCA patients.
- Results highlighted that GCA is associated with metabolic dysregulation, and glucocorticoid treatment increases the risk of diabetes and other health problems, indicating a need for alternative therapeutic approaches.
Objectives: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are overlapping autoinflammatory diseases affecting people over 50 years. The diseases are treated with immunosuppressive drugs such as prednisolone, methotrexate, leflunomide and tocilizumab. In this study, we assessed the immunogenicity and safety of SARS-CoV-2 vaccinations in these diseases (based on humoral and cellular immunity).
View Article and Find Full Text PDFGiant cell arteritis (GCA) is a granulomatous large-vessel vasculitis that affects adults above 50 years of age. In GCA, circulating monocytes are recruited to the inflamed arteries. With cues from the vascular microenvironment, they differentiate into macrophages and play important roles in the pathogenesis of GCA via pro-inflammatory cytokine production and vascular remodeling.
View Article and Find Full Text PDFObjectives: GCA is a large vessel vasculitis in which metabolically active immune cells play an important role. GCA diagnosis is based on CRP/ESR and temporal artery biopsies (TABs), in combination with 18F-fluorodeoxyglucose ([18F]FDG)-PET/CT relying on enhanced glucose uptake by glycolytic macrophages. Here, we studied circulating Pyruvate Kinase M2 (PKM2), a glycolytic enzyme, as a possible systemic marker of vessel wall inflammation in GCA.
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- Distinct cell types develop from embryonic stem cells (ESCs) via carefully coordinated gene expression changes regulated by transcription factors and chromatin complexes.
- A study using an epigenetic screening method uncovered the importance of chromatin-related factors in directing ESC differentiation into mesodermal and endodermal lineages, highlighting a specific chromatin protein, ARID4B.
- Although ARID4B-deficient ESCs maintain pluripotency, the absence of ARID4B leads to issues in the activation of genes necessary for mesodermal and endodermal development, with its deficiency also affecting the balance of specific histone modifications at key developmental genes.