Publications by authors named "Iddo Nadav Weiner"
Article Synopsis
- Primary sclerosing cholangitis (PSC) involves harmful inflammation and scarring of bile ducts and has been linked to certain gut bacteria, particularly Klebsiella pneumoniae and Enterococcus gallinarum, found abundantly in PSC patients' fecal samples.* -
- Research shows that carriers of these bacteria experience more severe disease and inflammation, validated through experiments in mice where PSC-related Kp worsens liver injury.* -
- A developed lytic phage cocktail effectively targets and reduces Kp levels, improving liver health in affected mice, suggesting this treatment could be a promising strategy for managing PSC.*
Human gut commensals are increasingly suggested to impact non-communicable diseases, such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a daunting unmet challenge. In four geographically distinct IBD cohorts (n = 537), we identify a clade of Klebsiella pneumoniae (Kp) strains, featuring a unique antibiotics resistance and mobilome signature, to be strongly associated with disease exacerbation and severity. Transfer of clinical IBD-associated Kp strains into colitis-prone, germ-free, and colonized mice enhances intestinal inflammation.
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