Publications by authors named "Idd Shabani"
Background: Standardized Wilms tumor treatment protocols exist for low- and middle-income countries, but outcomes equivalent to high-income countries are not achieved outside of clinical trials. As Wilms tumor treatment protocols in Africa shift with increasing resource capacity, it is not known how treatment compliance to each stage of therapy affects outcomes and where the critical breakpoints are for protocol adherence in clinical practice.
Procedure: We describe both treatment outcomes and treatment protocol adherence in a retrospective single-center cohort study of pediatric Wilms tumor patients at a zonal cancer referral hospital in Tanzania from 2016 to 2019, treated per the International Society of Paediatric Oncology standard (2016-2017) or Tanzania adapted (2018-2019) therapy protocols.
Article Synopsis
- Local healthcare workers screened children aged 2-16 for stroke risk using Transcranial Doppler (TCD) ultrasonography, determining eligibility for hydroxyurea treatment based on their screening results.
- The trial has shown a high prevalence of stroke risk indicators and splenomegaly among participants, with expectations to evaluate the benefits of hydroxyurea and increase access to treatment in Tanzania.