Publications by authors named "Ida Daniela Perrotta"
Article Synopsis
- A smart temperature-responsive drug release system was created to enhance the effectiveness of tetracycline (TC) in treating bacterial infections.
- The system uses niosomes made with SPAN60, cholesterol, and a phase change material (PCM), showing stable size and biocompatibility over three months.
- The research revealed that the niosomes released more tetracycline at higher temperatures, which improved their antibacterial effects against certain bacteria while reducing the need for higher antibiotic doses.
Anderson-Fabry disease (AFD) is an X-linked multisystemic disorder with a heterogeneous phenotype, resulting from deficiency of the lysosomal enzyme α-galactosidase A (α-Gal A) and leading to globotriaosylceramide systemic accumulation. Lysosomal storage is not the unique player in organ failure and different mechanisms could drive tissue damage, including endoplasmic reticulum (ER) stress and its related signaling pathway's activation. We identified a new missense variant in the signal peptide of gene, c.
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- Mitochondrial alterations are linked to various cancers, including multiple myeloma (MM), and natural flavonoids like Hesperetin and Naringenin are studied for their potential to target mitochondrial dynamics by affecting the protein Drp1.
- The study involved multiple methods such as molecular docking, cell viability tests, and transcriptomic analyses to explore how Hes and Nar influence MM cells, including effects on cell growth and apoptosis.
- Results showed that Hes and Nar inhibit Drp1, leading to changes in mitochondrial structure, reduced cancer cell survival and growth, and altered cellular metabolism by down-regulating key transcription factors involved in lipogenesis.
Article Synopsis
- Alendronate (ALN) is a bisphosphonate commonly used for treating osteoporosis and certain bone cancers, but its connection to osteonecrosis of the jaws (ONJ) remains poorly understood.
- In this study, researchers examined how various concentrations of ALN affect the viability and functionality of human periodontal ligament stem cells (hPDLSCs), finding that higher concentrations (10 μM or above) significantly reduced cell viability and induced cell death at 50 μM.
- The findings also indicated that low ALN concentrations (2-5 μM) decreased oxidative stress in hPDLSCs, while higher concentrations (50 μM) increased it, highlighting a complex response in cell mobility and health due to AL
Background: The receptor for advanced glycation-end products (RAGE) and its ligands have been implicated in obesity and associated inflammatory processes as well as in metabolic alterations like diabetes. In addition, RAGE-mediated signaling has been reported to contribute to the metastatic progression of breast cancer (BC), although mechanistic insights are still required. Here, we provide novel findings regarding the transcriptomic landscape and the molecular events through which RAGE may prompt aggressive features in estrogen receptor (ER)-positive BC.
View Article and Find Full Text PDFMetallic nanoparticles show plasmon resonance phenomena when irradiated with electromagnetic radiation of a suitable wavelength, whose value depends on their composition, size, and shape. The damping of the surface electron oscillation causes a release of heat, which causes a large increase in local temperature. Furthermore, this increase is enhanced when nanoparticle aggregation phenomena occur.
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- Lidocaine, a local anaesthetic, can form self-assembling molecular aggregates known as lidosomes, which can function as both a drug and a carrier.
- This study explored how to create optimal lidosomes using lidocaine and its hydrochloride variants with various hydration solutions, focusing on size, stability, and drug retention.
- The findings indicated that lidocaine formed more effective vesicular carriers than its hydrochloride form and could enhance skin penetration, serving as a long-lasting drug depot for topical therapies.
Article Synopsis
- * Researchers found that GPER1 is significantly increased in tumor cells of WM patients when compared to normal B cells.
- * The GPER1-selective agonist G-1 (Tespria) induces cell cycle arrest and apoptosis in cancer cells, activating the TP53 pathway and showing promise for further clinical development in WM treatment.
Objectives: Developing novel therapeutic approaches to defeat chemoresistance is the major goal of ovarian cancer research. Induction of ferroptosis has shown promising antitumor effects in ovarian cancer cells, but the existence of still undefined genetic and metabolic determinants of susceptibility has so far limited the application of ferroptosis inducers .
Methods: Erastin and/or the iron compound ferlixit were used to trigger ferroptosis in HEY, COV318, PEO4, and A2780CP ovarian cancer cell lines.
Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer-associated fibroblasts.
Clin Transl Med
November 2021
Among the prognostic and predictive biomarkers of breast cancer (BC), the role of estrogen receptor (ER)α wild-type has been acknowledged, although the action of certain ERα splice variants has not been elucidated. Insulin/insulin receptor (IR) axis has also been involved in the progression and metastasis of BC. For instance, hyperinsulinemia, which is often associated with obesity and type 2 diabetes, may be a risk factor for BC.
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- * Over an eight-week period, rats were given different diets, and while biochemical and metabolic changes were minimal, improvements in heart function after ischemic events were noted in groups receiving supplements.
- * The findings suggest that functional foods like WDPP and HSOP may effectively address nutritional challenges and provide heart protection, while also potentially aiding those with dysphagia due to their suitable texture.
Article Synopsis
- Exosomes in the Malpighian tubules of Calathus fuscipes were studied using transmission electron microscopy, revealing numerous multivesicular bodies in the cells.
- These bodies contain 15 to 80 small vesicles formed from late endosomes and release their contents as exosomes into the extracellular space.
- The findings pave the way for further research into the significance of exosomes in the functioning of tubule cells and communication between cells in insects.
Human podocytes are highly specialized cells with a key role in kidney physiology. Alteration of their structure as a consequence of injury or developmental failure leads to severe renal diseases. Although several studies have tried to elucidate the molecular framework of this cellular system, the functional bases for the maintenance of podocytes in their specialized state to sustain kidney barrier filtration are not completely understood.
View Article and Find Full Text PDFVolatile compounds produced by adults of Anchomenus dorsalis under undisturbed and disturbed conditions were investigated with an all-glass aeration apparatus. GC-MS analysis of the crude extracts from undisturbed and disturbed adults highlighted four major volatile compounds, undecane, heneicosane, Z-9 tricosene and tricosane, of which significantly more undecane was released by disturbed adults compared to undisturbed beetles. The pygidial glands of adults of Anchomenus dorsalis were investigated using light and Transmission Electron Microscopy (TEM).
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