Differential localization of voltage-gated potassium channels during metamorphosis.

Neuronal excitability is determined by the combination of different ion channels and their sub-neuronal localization. This study utilizes protein trap fly strains with endogenously tagged channels to analyze the spatial expression patterns of the four Shaker-related voltage-gated potassium channels, K1-4, in the larval, pupal, and adult ventral nerve cord. We find that all four channels (Shaker, K1; Shab, K2; Shaw, K3; and Shal, K4) each show different spatial expression patterns in the ventral nerve cord and are predominantly targeted to different sub-neuronal compartments.

"It's both a strength and a drawback." How therapists' personal qualities are experienced in their professional work.

The aim of this study was to gain knowledge about how the integration of personal and professional experiences affects therapeutic work. : Therapists ( = 14) who had been recommended by their leaders at their individual workplaces were interviewed twice with semi-structured qualitative interviews, which were then subjected to thematic and Interpretative Phenomenological Analysis. All the therapists in the sample described their personal qualities as an experienced tension between their personal strengths and vulnerabilities in the therapeutic setting.