Publications by authors named "Ida Benedikte Gottschalck"
Low-dose azathioprine and allopurinol versus azathioprine monotherapy in patients with ulcerative colitis (AAUC): An investigator-initiated, open, multicenter, parallel-arm, randomised controlled trial.
EClinicalMedicine
March 2022
Article Synopsis
- The study aims to compare the effectiveness of low-dose azathioprine combined with allopurinol to standard azathioprine alone in inducing remission in patients with moderate-to-severe ulcerative colitis.
- In this randomized trial involving 89 patients, those receiving the combination therapy had a significantly higher remission rate (43%) compared to those on monotherapy (21%) after one year.
- Although both treatment groups experienced adverse events, the combination therapy group showed promising results and potential benefits for patients struggling with ulcerative colitis.
Patients suffering from Crohn's disease (CD) are at increased risk of infectious diseases, such as pneumococcal infection. The risk increases with immunotherapy. Pneumococcal infection can be prevented by vaccination.
View Article and Find Full Text PDFBackground: Patients with Crohn's disease (CD) have a higher risk of infectious diseases including pneumococcal infections, and the risk increases with immunotherapy. The primary endpoint of this study was to investigate the specific antibody response to two pneumococcal vaccines in CD patients with and without immunosuppressive treatment four weeks post vaccination.
Methods: In a randomized trial of the 23-valent pneumococcal polysaccharide vaccine (PPV23) and the 13-valent pneumococcal conjugated vaccine (PCV13), a group of CD patients treated with immunosuppressive drugs (IS) alone or in combination with TNF-α antagonists were compared to a group of CD patients not treated with any of these drugs (untreated).